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Int. J. Mol. Sci. 2018, 19(2), 390; https://doi.org/10.3390/ijms19020390

Unravelling Immunoglobulin G Fc N-Glycosylation: A Dynamic Marker Potentiating Predictive, Preventive and Personalised Medicine

1
,
1
,
2,3
,
1,4,5
and
1,6,7,*
1
School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Australia
2
Department of Twin Research & Genetic Epidemiology, King’s College London, London SE1 7EH, UK
3
Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
4
School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley 6102, Australia
5
Co-Operative Research Centre for Mental Health, Carlton South 3053, Australia
6
Key Municipal Laboratory of Clinical Epidemiology, Capital Medical University, Beijing 100054, China
7
Taishan Medical University, Taian Shi 271016, China
*
Author to whom correspondence should be addressed.
Received: 28 November 2017 / Revised: 10 January 2018 / Accepted: 24 January 2018 / Published: 29 January 2018
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1726 KB, uploaded 29 January 2018]   |  

Abstract

Multiple factors influence immunoglobulin G glycosylation, which in turn affect the glycoproteins’ function on eliciting an anti-inflammatory or pro-inflammatory response. It is prudent to underscore these processes when considering the use of immunoglobulin G N-glycan moieties as an indication of disease presence, progress, or response to therapeutics. It has been demonstrated that the altered expression of genes that encode enzymes involved in the biosynthesis of immunoglobulin G N-glycans, receptors, or complement factors may significantly modify immunoglobulin G effector response, which is important for regulating the immune system. The immunoglobulin G N-glycome is highly heterogenous; however, it is considered an interphenotype of disease (a link between genetic predisposition and environmental exposure) and so has the potential to be used as a dynamic biomarker from the perspective of predictive, preventive, and personalised medicine. Undoubtedly, a deeper understanding of how the multiple factors interact with each other to alter immunoglobulin G glycosylation is crucial. Herein we review the current literature on immunoglobulin G glycoprotein structure, immunoglobulin G Fc glycosylation, associated receptors, and complement factors, the downstream effector functions, and the factors associated with the heterogeneity of immunoglobulin G glycosylation. View Full-Text
Keywords: immunoglobulin G; glycosylation; effector function; biomarker; environmental factors; glycomics immunoglobulin G; glycosylation; effector function; biomarker; environmental factors; glycomics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Russell, A.; Adua, E.; Ugrina, I.; Laws, S.; Wang, W. Unravelling Immunoglobulin G Fc N-Glycosylation: A Dynamic Marker Potentiating Predictive, Preventive and Personalised Medicine. Int. J. Mol. Sci. 2018, 19, 390.

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