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Int. J. Mol. Sci. 2018, 19(1), 54; https://doi.org/10.3390/ijms19010054

Development of Antibody Therapeutics against Flaviviruses

The Biodesign Institute, School of Life Sciences, Arizona State University, 1001 S. McAllister Avenue, Tempe, AZ 85287, USA
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Author to whom correspondence should be addressed.
Received: 30 November 2017 / Revised: 20 December 2017 / Accepted: 22 December 2017 / Published: 25 December 2017
(This article belongs to the Special Issue Recombinant Proteins)
View Full-Text   |   Download PDF [1925 KB, uploaded 25 December 2017]   |  

Abstract

Recent outbreaks of Zika virus (ZIKV) highlight the urgent need to develop efficacious interventions against flaviviruses, many of which cause devastating epidemics around the world. Monoclonal antibodies (mAb) have been at the forefront of treatment for cancer and a wide array of other diseases due to their specificity and potency. While mammalian cell-produced mAbs have shown promise as therapeutic candidates against several flaviviruses, their eventual approval for human application still faces several challenges including their potential risk of predisposing treated patients to more severe secondary infection by a heterologous flavivirus through antibody-dependent enhancement (ADE). The high cost associated with mAb production in mammalian cell cultures also poses a challenge for the feasible application of these drugs to the developing world where the majority of flavivirus infection occurs. Here, we review the current therapeutic mAb candidates against various flaviviruses including West Nile (WNV), Dengue virus (DENV), and ZIKV. The progress of using plants for developing safer and more economical mAb therapeutics against flaviviruses is discussed within the context of their expression, characterization, downstream processing, neutralization, and in vivo efficacy. The progress of using plant glycoengineering to address ADE, the major impediment of flavivirus therapeutic development, is highlighted. These advancements suggest that plant-based systems are excellent alternatives for addressing the remaining challenges of mAb therapeutic development against flavivirus and may facilitate the eventual commercialization of these drug candidates. View Full-Text
Keywords: flavivirus; antibody; monoclonal antibody (mAb); therapeutics; plant-made antibody; antibody-dependent enhancement (ADE); West Nile virus (WNV); Dengue virus (DENV); Zika virus (ZIKV); plant-made pharmaceuticals (PMP) flavivirus; antibody; monoclonal antibody (mAb); therapeutics; plant-made antibody; antibody-dependent enhancement (ADE); West Nile virus (WNV); Dengue virus (DENV); Zika virus (ZIKV); plant-made pharmaceuticals (PMP)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Sun, H.; Chen, Q.; Lai, H. Development of Antibody Therapeutics against Flaviviruses. Int. J. Mol. Sci. 2018, 19, 54.

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