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Int. J. Mol. Sci. 2018, 19(1), 223; doi:10.3390/ijms19010223

Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster

1
Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Strasse 6, D-24118 Kiel, Germany
2
Institute of Nutritional Medicine, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
3
Department of Safety and Quality of Fruit and Vegetables, Max Rubner Institute, Haid-und-Neu-Strasse 9, D-76131 Karlsruhe, Germany
*
Author to whom correspondence should be addressed.
Received: 30 November 2017 / Revised: 19 December 2017 / Accepted: 5 January 2018 / Published: 11 January 2018
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Abstract

In this study, we tested the effect of the stilbene resveratrol on life span, body composition, locomotor activity, stress response, and the expression of genes encoding proteins centrally involved in ageing pathways in the model organism Drosophila melanogaster. Male and female w1118 D. melanogaster were fed diets based on sucrose, corn meal, and yeast. Flies either received a control diet or a diet supplemented with 500 µmol/L resveratrol. Dietary resveratrol did not affect mean, median, and maximal life span of male and female flies. Furthermore, body composition remained largely unchanged following the resveratrol supplementation. Locomotor activity, as determined by the climbing index, was not significantly different between control and resveratrol-supplemented flies. Resveratrol-fed flies did not exhibit an improved stress response towards hydrogen peroxide as compared to controls. Resveratrol did not change mRNA steady levels of antioxidant (catalase, glutathione-S-transferase, NADH dehydrogenase, glutathione peroxidase, superoxide dismutase 2) and longevity-related genes, including sirtuin 2, spargel, and I’m Not Dead Yet. Collectively, present data suggest that resveratrol does not affect life span, body composition, locomotor activity, stress response, and longevity-associated gene expression in w1118 D. melanogaster. View Full-Text
Keywords: resveratrol; Drosophila; healthy ageing; life span; longevity resveratrol; Drosophila; healthy ageing; life span; longevity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Staats, S.; Wagner, A.E.; Kowalewski, B.; Rieck, F.T.; Soukup, S.T.; Kulling, S.E.; Rimbach, G. Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster. Int. J. Mol. Sci. 2018, 19, 223.

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