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Int. J. Mol. Sci. 2018, 19(1), 33; doi:10.3390/ijms19010033

Chemical Composition and Bioactivity of Essential Oil from Blepharocalyx salicifolius

1
Institute of Biosciences of Botucatu, Laboratory of Bacteriology, Unesp-São Paulo State University, Botucatu CEP 18618-000, Brazil
2
Institute of Biomedical Sciences, Trypanosomatids Laboratory (LATRI), UFU-Federal University of Uberlândia, Uberlândia CEP 38400-902, Brazil
3
Institute of Biosciences of Botucatu, Laboratory of Fungi Biology, Unesp-São Paulo State University, Botucatu CEP 18618-000, Brazil
4
Institute of Biosciences of Botucatu, Laboratory of Phytomedicines, Pharmacology and Biotechnology (PhytoPharmaTech), Unesp-São Paulo State University, Botucatu CEP 18618-000, Brazil
*
Author to whom correspondence should be addressed.
Received: 6 November 2017 / Revised: 26 November 2017 / Accepted: 13 December 2017 / Published: 4 January 2018
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Abstract

Natural products represent a source of biologically active molecules that have an important role in drug discovery. The aromatic plant Blepharocalyx salicifolius has a diverse chemical constitution but the biological activities of its essential oils have not been thoroughly investigated. The aims of this paper were to evaluate in vitro cytotoxic, antifungal and antibacterial activities of an essential oil from leaves of B. salicifolius and to identify its main chemical constituents. The essential oil was extracted by steam distillation, chemical composition was determined by gas chromatography/mass spectrometry, and biological activities were performed by a microdilution broth method. The yield of essential oil was 0.86% (w/w), and the main constituents identified were bicyclogermacrene (17.50%), globulol (14.13%), viridiflorol (8.83%), γ-eudesmol (7.89%) and α-eudesmol (6.88%). The essential oil was cytotoxic against the MDA-MB-231 (46.60 μg·mL−1) breast cancer cell line, being more selective for this cell type compared to the normal breast cell line MCF-10A (314.44 μg·mL−1). Flow cytometry and cytotoxicity results showed that this oil does not act by inducing cell death, but rather by impairment of cellular metabolism specifically of the cancer cells. Furthermore, it presented antifungal activity against Paracoccidioides brasiliensis (156.25 μg·mL−1) but was inactive against other fungi and bacteria. Essential oil from B. salicifolius showed promising biological activities and is therefore a source of molecules to be exploited in medicine or by the pharmaceutical industry. View Full-Text
Keywords: bicyclogermacrene; globulol; viridiflorol; eudesmol; breast cancer; MDA-MB-231; MCF-10A; Paracoccidioides brasiliensis; flow cytometry bicyclogermacrene; globulol; viridiflorol; eudesmol; breast cancer; MDA-MB-231; MCF-10A; Paracoccidioides brasiliensis; flow cytometry
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MDPI and ACS Style

Furtado, F.B.; Borges, B.C.; Teixeira, T.L.; Garces, H.G.; Almeida Junior, L.D.; Alves, F.C.B.; Silva, C.V.; Fernandes Junior, A. Chemical Composition and Bioactivity of Essential Oil from Blepharocalyx salicifolius. Int. J. Mol. Sci. 2018, 19, 33.

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