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Int. J. Mol. Sci. 2018, 19(1), 206; doi:10.3390/ijms19010206

Mustn1: A Developmentally Regulated Pan-Musculoskeletal Cell Marker and Regulatory Gene

Department of Life Sciences, New York Institute of Technology, Old Westbury, NY 11568-8000, USA
Received: 4 December 2017 / Revised: 26 December 2017 / Accepted: 6 January 2018 / Published: 12 January 2018
(This article belongs to the Special Issue Biological Basis of Musculoskeletal Regeneration)
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Abstract

The Mustn1 gene encodes a small nuclear protein (~9.6 kDa) that does not belong to any known family. Its genomic organization consists of three exons interspersed by two introns and it is highly homologous across vertebrate species. Promoter analyses revealed that its expression is regulated by the AP family of transcription factors, especially c-Fos, Fra-2 and JunD. Mustn1 is predominantly expressed in the major tissues of the musculoskeletal system: bone, cartilage, skeletal muscle and tendon. Its expression has been associated with normal embryonic development, postnatal growth, exercise, and regeneration of bone and skeletal muscle. Moreover, its expression has also been detected in various musculoskeletal pathologies, including arthritis, Duchenne muscular dystrophy, other skeletal muscle myopathies, clubfoot and diabetes associated muscle pathology. In vitro and in vivo functional perturbation revealed that Mustn1 is a key regulatory molecule in myogenic and chondrogenic lineages. This comprehensive review summarizes our current knowledge of Mustn1 and proposes that it is a new developmentally regulated pan-musculoskeletal marker as well as a key regulatory protein for cell differentiation and tissue growth. View Full-Text
Keywords: Mustn1; musculoskeletal; marker; cartilage; skeletal muscle; bone; tendon Mustn1; musculoskeletal; marker; cartilage; skeletal muscle; bone; tendon
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Hadjiargyrou, M. Mustn1: A Developmentally Regulated Pan-Musculoskeletal Cell Marker and Regulatory Gene. Int. J. Mol. Sci. 2018, 19, 206.

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