The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts
Abstract
:1. Introduction
2. Retinoblastoma (RB) Role in Double Strand Breaks (DSB) Repair
3. RB Role Silencing Repetitive Sequences
4. RB Role in Telomere Maintenance
5. RB Role in Centromere Structure and Chromosome Instability (CIN)
6. Conclusions
Acknowledgments
Conflicts of Interest
Abbreviations
RB | Retinoblastoma |
CDK | Cyclin-dependent kinases |
PP1 | Protein phosphatase 1 |
HAT | histone acetyltransferases |
HDAC | Histone deacetylase |
BRCA1 | Breast cancer susceptibility gene 1 |
RPA | Replication protein A |
ATM | Ataxia telangiectasia mutated kinase |
ATR | Ataxia telangiectasia RAD3-related kinase |
DSB | DNA double strand breaks |
IR | Ionizing radiation |
HR | Homologous recombination |
NHEJ | Non-homologous end joining |
PARPi | Poly (ADP-ribose) polymerase inhibitors |
MRN | MRE11-RAD50-NBS1 complex |
ssDNA | Single-stranded DNA |
Chk1 | Checkpoint kinase 1 |
BRCT | BRCA1 C terminal domain |
MEF | Mouse embryonic fibroblasts |
NER | Nucleotide excision repair |
DNA-PK | DNA protein kinase |
DKO | Double knock-out (p107−/−; p130−/−) |
TKO | Triple knock-out (RB−/−;p107−/−; p130−/−) |
CIN | Chromosome instability |
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Vélez-Cruz, R.; Johnson, D.G. The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts. Int. J. Mol. Sci. 2017, 18, 1776. https://doi.org/10.3390/ijms18081776
Vélez-Cruz R, Johnson DG. The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts. International Journal of Molecular Sciences. 2017; 18(8):1776. https://doi.org/10.3390/ijms18081776
Chicago/Turabian StyleVélez-Cruz, Renier, and David G. Johnson. 2017. "The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts" International Journal of Molecular Sciences 18, no. 8: 1776. https://doi.org/10.3390/ijms18081776