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Int. J. Mol. Sci. 2017, 18(8), 1657; doi:10.3390/ijms18081657

Polycomb Repressor Complex 2 in Genomic Instability and Cancer

1
Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Greece
2
Embiodiagnostics Ltd., 71202 Heraklion, Greece
3
Department of Medical Laboratories, Faculty of Health and Caring Professions, Technological and Educational Institute of Athens, 12243 Athens, Greece
4
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, 70013 Heraklion, Greece
*
Author to whom correspondence should be addressed.
Received: 29 June 2017 / Revised: 19 July 2017 / Accepted: 25 July 2017 / Published: 30 July 2017
(This article belongs to the Special Issue Mechanisms Leading to Genomic Instability)
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Abstract

Polycomb repressor complexes PRC1 and PRC2 regulate chromatin compaction and gene expression, and are widely recognized for their fundamental contributions to developmental processes. Herein, we summarize the existing evidence and molecular mechanisms linking PRC-mediated epigenetic aberrations to genomic instability and malignancy, with a particular focus on the role of deregulated PRC2 in tumor suppressor gene expression, the DNA damage response, and the fidelity of DNA replication. We also discuss some of the recent advances in the development of pharmacological and dietary interventions affecting PRC2, which point to promising applications for the prevention and management of human malignancies. View Full-Text
Keywords: polycomb; polycomb repressor complex 2; enhancer of zeste homolog 2; DNA damage response; diet; inhibitors polycomb; polycomb repressor complex 2; enhancer of zeste homolog 2; DNA damage response; diet; inhibitors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Veneti, Z.; Gkouskou, K.K.; Eliopoulos, A.G. Polycomb Repressor Complex 2 in Genomic Instability and Cancer. Int. J. Mol. Sci. 2017, 18, 1657.

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