Polycomb Repressor Complex 2 in Genomic Instability and Cancer
AbstractPolycomb repressor complexes PRC1 and PRC2 regulate chromatin compaction and gene expression, and are widely recognized for their fundamental contributions to developmental processes. Herein, we summarize the existing evidence and molecular mechanisms linking PRC-mediated epigenetic aberrations to genomic instability and malignancy, with a particular focus on the role of deregulated PRC2 in tumor suppressor gene expression, the DNA damage response, and the fidelity of DNA replication. We also discuss some of the recent advances in the development of pharmacological and dietary interventions affecting PRC2, which point to promising applications for the prevention and management of human malignancies. View Full-Text
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Veneti, Z.; Gkouskou, K.K.; Eliopoulos, A.G. Polycomb Repressor Complex 2 in Genomic Instability and Cancer. Int. J. Mol. Sci. 2017, 18, 1657.
Veneti Z, Gkouskou KK, Eliopoulos AG. Polycomb Repressor Complex 2 in Genomic Instability and Cancer. International Journal of Molecular Sciences. 2017; 18(8):1657.Chicago/Turabian Style
Veneti, Zoe; Gkouskou, Kalliopi K.; Eliopoulos, Aristides G. 2017. "Polycomb Repressor Complex 2 in Genomic Instability and Cancer." Int. J. Mol. Sci. 18, no. 8: 1657.
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