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Int. J. Mol. Sci. 2017, 18(8), 1767; doi:10.3390/ijms18081767

The Mechanistic Links between Insulin and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl Channel

1
Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
2
Department of Bio-Ionomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
3
Japan Institute for Food Education and Health, St. Agnes’ University, Kyoto 602-8013, Japan
Received: 3 July 2017 / Revised: 31 July 2017 / Accepted: 10 August 2017 / Published: 14 August 2017
(This article belongs to the Special Issue Physiological and Pathological Roles of ABC Transporters)
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Abstract

The cystic fibrosis transmembrane conductance regulator (CFTR) Cl channel belongs to the ATP-binding cassette (ABC) transporter superfamily and regulates Cl secretion in epithelial cells for water secretion. Loss-of-function mutations to the CFTR gene cause dehydrated mucus on the apical side of epithelial cells and increase the susceptibility of bacterial infection, especially in the airway and pulmonary tissues. Therefore, research on the molecular properties of CFTR, such as its gating mechanism and subcellular trafficking, have been intensively pursued. Dysregulated CFTR trafficking is one of the major pathological hallmarks in cystic fibrosis (CF) patients bearing missense mutations in the CFTR gene. Hormones that activate cAMP signaling, such as catecholamine, have been found to regulate the intracellular trafficking of CFTR. Insulin is one of the hormones that regulate cAMP production and promote trafficking of transmembrane proteins to the plasma membrane. The functional interactions between insulin and CFTR have not yet been clearly defined. In this review article, I review the roles of CFTR in epithelial cells, its regulatory role in insulin secretion, and a mechanism of CFTR regulation by insulin. View Full-Text
Keywords: CFTR; insulin; epithelial Cl transport CFTR; insulin; epithelial Cl transport
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Marunaka, Y. The Mechanistic Links between Insulin and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl Channel. Int. J. Mol. Sci. 2017, 18, 1767.

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