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Int. J. Mol. Sci. 2017, 18(8), 1740; doi:10.3390/ijms18081740

Epigenetic Regulation of Adipokines

1
Department of Nutritional Sciences, University of Connecticut, 216 Advanced Technology Laboratory Building, 1392 Storrs Road, Storrs, CT 06269, USA
2
Department of Nutritional Sciences, University of Connecticut, 211C Advanced Technology Laboratory Building, 1392 Storrs Road, Storrs, CT 06269, USA
*
Author to whom correspondence should be addressed.
Received: 7 July 2017 / Revised: 4 August 2017 / Accepted: 8 August 2017 / Published: 10 August 2017
(This article belongs to the Special Issue Adipokines)
View Full-Text   |   Download PDF [199 KB, uploaded 11 August 2017]

Abstract

Adipose tissue expansion in obesity leads to changes in the expression of adipokines, adipocyte-specific hormones that can regulate whole body energy metabolism. Epigenetic regulation of gene expression is a mechanism by which cells can alter gene expression through the modifications of DNA and histones. Epigenetic mechanisms, such as DNA methylation and histone modifications, are intimately tied to energy metabolism due to their dependence on metabolic intermediates such as S-adenosylmethionine and acetyl-CoA. Altered expression of adipokines in obesity may be due to epigenetic changes. The goal of this review is to highlight current knowledge of epigenetic regulation of adipokines. View Full-Text
Keywords: adipokines; epigenetics; obesity adipokines; epigenetics; obesity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pham, T.X.; Lee, J.-Y. Epigenetic Regulation of Adipokines. Int. J. Mol. Sci. 2017, 18, 1740.

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