Next Article in Journal
Epigenetic Regulation of Adipokines
Previous Article in Journal
Hypertension Caused by Lenvatinib and Everolimus in the Treatment of Metastatic Renal Cell Carcinoma
Previous Article in Special Issue
Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessCase Report
Int. J. Mol. Sci. 2017, 18(8), 1739; doi:10.3390/ijms18081739

Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients

Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
*
Author to whom correspondence should be addressed.
Received: 25 May 2017 / Revised: 24 June 2017 / Accepted: 3 August 2017 / Published: 10 August 2017
(This article belongs to the Special Issue Cannabinoid Signaling in Nervous System)
View Full-Text   |   Download PDF [180 KB, uploaded 10 August 2017]

Abstract

We report the cases of two young German male patients with treatment-resistant Tourette syndrome (TS), who suffer from incapacitating stuttering-like speech disfluencies caused by vocal blocking tics and palilalia. Case 1: a 19-year old patient received medical cannabis at a dose of 1 × 0.1 g cannabis daily. Case 2: a 16-year old patient initially received dronabinol at a maximum dose of 22.4–33.6 mg daily. Both treatments provided significant symptom improvement of vocal blocking tics as well as of comorbid conditions and were well tolerated. Thus, cannabis-based medicine appears to be effective in treatment-resistant TS patients with vocal blocking tics. View Full-Text
Keywords: Tourette syndrome; tics; nabiximols; blocking tics; dysfluency; cannabis Tourette syndrome; tics; nabiximols; blocking tics; dysfluency; cannabis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Jakubovski, E.; Müller-Vahl, K. Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients. Int. J. Mol. Sci. 2017, 18, 1739.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top