Taxol®: The First Microtubule Stabilizing Agent
AbstractTaxol®, an antitumor drug with significant activity, is the first microtubule stabilizing agent described in the literature. This short review of the mechanism of action of Taxol® emphasizes the research done in the Horwitz’ laboratory. It discusses the contribution of photoaffinity labeled analogues of Taxol® toward our understanding of the binding site of the drug on the microtubule. The importance of hydrogen/deuterium exchange experiments to further our insights into the stabilization of microtubules by Taxol® is addressed. The development of drug resistance, a major problem that arises in the clinic, is discussed. Studies describing differential drug binding to distinct β-tubulin isotypes are presented. Looking forward, it is suggested that the β-tubulin isotype content of a tumor may influence its responses to Taxol®. View Full-Text
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Yang, C.-P.H.; Horwitz, S.B. Taxol®: The First Microtubule Stabilizing Agent. Int. J. Mol. Sci. 2017, 18, 1733.
Yang C-PH, Horwitz SB. Taxol®: The First Microtubule Stabilizing Agent. International Journal of Molecular Sciences. 2017; 18(8):1733.Chicago/Turabian Style
Yang, Chia-Ping H.; Horwitz, Susan B. 2017. "Taxol®: The First Microtubule Stabilizing Agent." Int. J. Mol. Sci. 18, no. 8: 1733.
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