Next Article in Journal
The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice
Next Article in Special Issue
Correlation of Leukocyte Telomere Length Measurement Methods in Patients with Dyskeratosis Congenita and in Their Unaffected Relatives
Previous Article in Journal
Influence of a Virgin Olive Oil versus Butter Plus Cholesterol-Enriched Diet on Testicular Enzymatic Activities in Adult Male Rats
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessBrief Report
Int. J. Mol. Sci. 2017, 18(8), 1703; doi:10.3390/ijms18081703

Effects of Highly Polluted Environment on Sperm Telomere Length: A Pilot Study

1
CNR Institute of Clinical Physiology, Via Moruzzi 1, 56124 Pisa, Italy
2
Andrology Unit of the “San Francesco d’Assisi” Hospital, ASL Salerno, EcoFoodFertility Project Coordination Unit, Oliveto Citra, 84020 Salerno, Italy
3
Infertility Center, ASL Salerno Vallo della Lucania Hospital, 84078 Salerno, Italy
4
Reproduction Unit, HERA Center, Sant’Agata Li Battiati, 95030 Catania, Italy
*
Author to whom correspondence should be addressed.
Received: 12 July 2017 / Revised: 28 July 2017 / Accepted: 2 August 2017 / Published: 4 August 2017
(This article belongs to the Special Issue Role of Telomeres and Telomerase in Cancer and Aging)
View Full-Text   |   Download PDF [1554 KB, uploaded 4 August 2017]   |  

Abstract

High environmental pressure may impair male fertility by affecting sperm quality, but the real effect remains controversial. Herein, we assessed the influence of environmental exposure on telomere length (TL) in both leukocytes (LTL) and sperm cells (STL). A pilot biomonitoring study was conducted in 112 clinically healthy, normospermic men living in various areas of Campania region (South of Italy) with high (n = 57, High Group) or low (n = 55, Low Group) environmental pressure. TL analysis was assessed by quantitative real time-PCR. STL was not significantly correlated with either age (p = 0.6) or LTL (p = 0.7), but was significantly longer in the High Group compared with the Low Group (p = 0.04). No significant difference was observed between leukocyte TL in the High or Low Group. Our results showed that male residents in areas with high environment exposure had a significant increase in STL. This finding supports the view that the human semen is a sentinel biomarker of environmental exposure. View Full-Text
Keywords: environment; telomere length; sperm quality environment; telomere length; sperm quality
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Vecoli, C.; Montano, L.; Borghini, A.; Notari, T.; Guglielmino, A.; Mercuri, A.; Turchi, S.; Andreassi, M.G. Effects of Highly Polluted Environment on Sperm Telomere Length: A Pilot Study. Int. J. Mol. Sci. 2017, 18, 1703.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top