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Int. J. Mol. Sci. 2017, 18(8), 1699; doi:10.3390/ijms18081699

Prevention of Gastric Cancer: Eradication of Helicobacter Pylori and Beyond

1
Department of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake 470-1192, Japan
2
Division of Pathology, National Institute of Health Sciences, Tokyo 158-8501, Japan
3
Department of Gastric and Colorectal Surgery, Jilin University, Changchun 130000, China
*
Author to whom correspondence should be addressed.
Received: 17 July 2017 / Revised: 31 July 2017 / Accepted: 31 July 2017 / Published: 3 August 2017
(This article belongs to the Special Issue Inflammation and Cancer)
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Abstract

Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that H. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of H. pylori significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of H. pylori reduces the development of metachronous cancer in humans. However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. In this article, we discuss the effectiveness of H. pylori eradication and the morphological changes that occur in gastric dysplasia/cancer lesions. We further assess the control of gastric cancer using various chemopreventive agents. View Full-Text
Keywords: Helicobacter pylori; chronic atrophic gastritis; intestinal metaplasia; eradication; chemoprevention Helicobacter pylori; chronic atrophic gastritis; intestinal metaplasia; eradication; chemoprevention
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Tsukamoto, T.; Nakagawa, M.; Kiriyama, Y.; Toyoda, T.; Cao, X. Prevention of Gastric Cancer: Eradication of Helicobacter Pylori and Beyond. Int. J. Mol. Sci. 2017, 18, 1699.

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