Next Article in Journal
Clinical Outcomes and Co-Occurring Mutations in Patients with RUNX1-Mutated Acute Myeloid Leukemia
Next Article in Special Issue
Manipulation of the Growth Hormone-Insulin-Like Growth Factor (GH-IGF) Axis: A Treatment Strategy to Reverse the Effects of Early Life Developmental Programming
Previous Article in Journal
Melatonin Decreases Glucose Metabolism in Prostate Cancer Cells: A 13C Stable Isotope-Resolved Metabolomic Study
Previous Article in Special Issue
The Role of Growth Hormone and Insulin-Like Growth Factor-I in the Liver
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(8), 1621; doi:10.3390/ijms18081621

Growth Hormone’s Effect on Adipose Tissue: Quality versus Quantity

1
The Diabetes Institute at Ohio University, 108 Konneker Research Labs, Ohio University, Athens, OH 45701, USA
2
Edison Biotechnology Institute, 218 Konneker Research Labs, Ohio University, Athens, OH 45701, USA
*
Author to whom correspondence should be addressed.
Received: 21 June 2017 / Revised: 10 July 2017 / Accepted: 17 July 2017 / Published: 26 July 2017
(This article belongs to the Special Issue Growth Hormone: Therapeutic Possibilities)
View Full-Text   |   Download PDF [3031 KB, uploaded 26 July 2017]   |  

Abstract

Obesity is an excessive accumulation or expansion of adipose tissue (AT) due to an increase in either the size and/or number of its characteristic cell type, the adipocyte. As one of the most significant public health problems of our time, obesity and its associated metabolic complications have demanded that attention be given to finding effective therapeutic options aimed at reducing adiposity or the metabolic dysfunction associated with its accumulation. Growth hormone (GH) has therapeutic potential due to its potent lipolytic effect and resultant ability to reduce AT mass while preserving lean body mass. However, AT and its resident adipocytes are significantly more dynamic and elaborate than once thought and require one not to use the reduction in absolute mass as a readout of efficacy alone. Paradoxically, therapies that reduce GH action may ultimately prove to be healthier, in part because GH also possesses potent anti-insulin activities along with concerns that GH may promote the growth of certain cancers. This review will briefly summarize some of the newer complexities of AT relevant to GH action and describe the current understanding of how GH influences this tissue using data from both humans and mice. We will conclude by considering the therapeutic use of GH or GH antagonists in obesity, as well as important gaps in knowledge regarding GH and AT. View Full-Text
Keywords: adipose tissue; obesity; growth hormone; growth factor-1 (IGF-1); bovine GH transgenic (bGH) mice; growth hormone receptor (GHR)-/- mice; GHR antagonist (GHA) mice; acromegaly; Laron syndrome; growth hormone deficiency adipose tissue; obesity; growth hormone; growth factor-1 (IGF-1); bovine GH transgenic (bGH) mice; growth hormone receptor (GHR)-/- mice; GHR antagonist (GHA) mice; acromegaly; Laron syndrome; growth hormone deficiency
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Berryman, D.E.; List, E.O. Growth Hormone’s Effect on Adipose Tissue: Quality versus Quantity. Int. J. Mol. Sci. 2017, 18, 1621.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top