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Int. J. Mol. Sci. 2017, 18(7), 1372; doi:10.3390/ijms18071372

Effects of Non-Starch Polysaccharides on Inflammatory Bowel Disease

1,2,†
,
1,†
and
1,*
1
Laboratory of Molecular Nutrition, College of Food science and Engineering, National Engineering Laboratory for Deep Processing of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, China
2
Department of Animal Science and Technology, College of Hunan Biological and Electromechanical Polytechnic, Changsha 410128, China
These authors contribute equally to this work.
*
Author to whom correspondence should be addressed.
Received: 5 May 2017 / Revised: 12 June 2017 / Accepted: 18 June 2017 / Published: 27 June 2017
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents)
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Abstract

The incidence of inflammatory bowel disease (IBD) has increased considerably over the past few decades. In the present review, we discuss several disadvantages existing in the treatment of IBD and current understandings of the structures, sources, and natures of various kinds of non-starch polysaccharides (NSPs). Available evidences for the use of different sources of NSPs in IBD treatment both in vitro and in vivo are analyzed, including glucan from oat bran, mushroom, seaweed, pectin, gum, prebiotics, etc. Their potential mechanisms, especially their related molecular mechanism of protective action in the treatment and prevention of IBD, are also summarized, covering the anti-inflammation, immune-stimulating, and gut microbiota-modulating activities, as well as short-chain fatty acids (SCFAs) production, anti-oxidative stress accompanied with inflammation, the promotion of gastric epithelial cell proliferation and tissue healing, and the reduction of the absorption of toxins of NSPs, thus ameliorating the symptoms and reducing the reoccurrence rate of IBD. In summary, NSPs exhibit the potential to be promising agents for an adjuvant therapy and for the prevention of IBD. Further investigating of the crosstalk between immune cells, epithelial cells, and gut microorganisms in addition to evaluating the effects of different kinds and different molecular weights of NSPs will lead to well-designed clinical intervention trials and eventually improve the treatment and prevention of IBD. View Full-Text
Keywords: non-starch polysaccharide (NSP); inflammatory bowel disease (IBD); intervention; mechanism; SCFAs; gut microbiota; immune system; pro-inflammatory cytokines non-starch polysaccharide (NSP); inflammatory bowel disease (IBD); intervention; mechanism; SCFAs; gut microbiota; immune system; pro-inflammatory cytokines
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Nie, Y.; Lin, Q.; Luo, F. Effects of Non-Starch Polysaccharides on Inflammatory Bowel Disease. Int. J. Mol. Sci. 2017, 18, 1372.

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