Next Article in Journal
Age-Related Changes in Immunological and Physiological Responses Following Pulmonary Challenge
Next Article in Special Issue
Microbiota, Inflammation and Colorectal Cancer
Previous Article in Journal
A Panel of MicroRNAs as Diagnostic Biomarkers for the Identification of Prostate Cancer
Previous Article in Special Issue
Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(6), 1284; doi:10.3390/ijms18061284

p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer

1
Pathology Division, Gifu University Hospital, Gifu 501-1194, Japan
2
Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan
3
Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan
4
Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, 7-1. Kashima-tyo, Gifu 500-8513, Japan
*
Author to whom correspondence should be addressed.
Received: 27 April 2017 / Revised: 10 June 2017 / Accepted: 14 June 2017 / Published: 16 June 2017
(This article belongs to the Special Issue Inflammation and Cancer)
View Full-Text   |   Download PDF [3503 KB, uploaded 16 June 2017]   |  

Abstract

Ulcerative colitis (UC) is defined as an idiopathic inflammatory disorder primarily involving the mucosa and submucosa of the colon. UC-associated colon cancers (also known as colitic cancers) develop through the inflammation–dysplasia sequence, which is a major problem affecting the prognosis of patients with UC. It is therefore very important to detect malignancy from UC at an early stage. As precancerous lesions arising in UC, there are pathological adenomatous changes, basal cell changes, in situ anaplasia, clear cell changes, and pan-cellular change. It is considered that the mutation of the p53 gene plays a crucial role, and the protein expression of p53 in dysplastic crypts may serve as a good biomarker in the early stages of UC-associated colon carcinogenesis. Immunohistochemistry for p53 is a very valuable diagnostic tool in UC-associated colon cancers. However, protein expression of p53 is not always universal, and additional methods may be required to assess p53 status in UC-associated colon cancers. View Full-Text
Keywords: ulcerative colitis; p53; dysplasia; colitic cancer ulcerative colitis; p53; dysplasia; colitic cancer
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kobayashi, K.; Tomita, H.; Shimizu, M.; Tanaka, T.; Suzui, N.; Miyazaki, T.; Hara, A. p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer. Int. J. Mol. Sci. 2017, 18, 1284.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top