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Int. J. Mol. Sci. 2017, 18(6), 1159; doi:10.3390/ijms18061159

Significance of Phosphorylated Epidermal Growth Factor Receptor and Its Signal Transducers in Human Soft Tissue Sarcoma

1
Department of Surgery, Clinical School of Prince of Wales Hospital, Faculty of Medicine, University of New South Wales, Sydney 2001, Australia
2
Sarcoma and Nanooncology Group, Adult Cancer Program, Lowy Cancer Research Centre, Clinical School of Prince of Wales Hospital, Faculty of Medicine, University of New South Wales, Sydney 2001, Australia
3
Department of Paediatric and Burns Surgery, Lady Cilento Children’s Hospital, Children’s Health Queensland, Brisbane 4000, Australia
4
Department of Medical Oncology, Clinical School of Prince of Wales Hospital, Faculty of Medicine, University of New South Wales, Sydney 2001, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Terrence Piva
Received: 5 May 2017 / Revised: 22 May 2017 / Accepted: 25 May 2017 / Published: 30 May 2017
(This article belongs to the Special Issue Alterations to Signalling Pathways in Cancer Cells)
View Full-Text   |   Download PDF [1506 KB, uploaded 31 May 2017]   |  

Abstract

Previous studies have shown that total epidermal growth factor receptor (EGFR) protein is highly expressed in soft tissue sarcoma (STS). We aimed to investigate the significance of phosphorylated-EGFR (pEGFR) and its activated-downstream signal transducers in STS tissue samples. A tissue microarray comprising 87 STS samples was assessed for total EGFR, pEGFR and its phosphorylated signal transducers and expression was correlated with clinicopathlogical parameters including patient outcome. Although the expression of total EGFR was significantly associated with adverse STS histologic grade (p = 0.004) and clinical stage (p = 0.012) similar to pEGFR, phosphorylated protein kinase B (pAkt) and phosphorylated extracellular signal regulated kinase (pERK), it is not a prognostic factor for survival. By contrast, the expression of pEGFR is an independent factor for cancer specific survival, while pERK is an independent prognostic factor for both overall and cancer specific survival in STS (p < 0.05, Cox proportional hazard model and log-rank test) in addition to the recognised factors of tumour grade and clinical stage. pERK and pEGFR are new independent prognostic factors for overall and/or cancer specific survival in STS. The expression of EGFR/pEGFR, and their associated downstream signal transducers, was associated with STS progression, suggesting that EGFR downstream signalling pathways may jointly support STS cell survival. View Full-Text
Keywords: EGFR; pEGFR; pAkt; pERK; soft tissue sarcoma; grade; stage; overall survival; cancer specific survival; immunohistochemistry EGFR; pEGFR; pAkt; pERK; soft tissue sarcoma; grade; stage; overall survival; cancer specific survival; immunohistochemistry
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MDPI and ACS Style

Yang, J.-L.; Gupta, R.D.; Goldstein, D.; Crowe, P.J. Significance of Phosphorylated Epidermal Growth Factor Receptor and Its Signal Transducers in Human Soft Tissue Sarcoma. Int. J. Mol. Sci. 2017, 18, 1159.

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