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Int. J. Mol. Sci. 2017, 18(6), 1129; doi:10.3390/ijms18061129

The Importance of Pericytes in Healing: Wounds and other Pathologies

1
Centre for Regenerative Medicine, Future Industries Institute, University of South Australia, Mawson Lakes 5095, Australia
2
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, Australia
3
Cooperative Research Centre for Cell Therapy Manufacturing, North Terrace, Adelaide 5000, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Terrence Piva
Received: 13 April 2017 / Revised: 12 May 2017 / Accepted: 15 May 2017 / Published: 24 May 2017
(This article belongs to the Special Issue Wound Repair and Regeneration)
View Full-Text   |   Download PDF [450 KB, uploaded 25 May 2017]   |  

Abstract

Much of current research investigates the beneficial properties of mesenchymal stem cells (MSCs) as a treatment for wounds and other forms of injury. In this review, we bring attention to and discuss the role of the pericyte, a cell type which shares much of the differentiation potential and regenerative properties of the MSC as well as specific roles in the regulation of angiogenesis, inflammation and fibrosis. Pericytes have been identified as dysfunctional or depleted in many disease states, and observing the outcomes of pericyte perturbation in models of disease and wound healing informs our understanding of overall pericyte function and identifies these cells as an important target in the development of therapies to encourage healing. View Full-Text
Keywords: pericyte; MSC; wound healing; cell therapy pericyte; MSC; wound healing; cell therapy
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Thomas, H.M.; Cowin, A.J.; Mills, S.J. The Importance of Pericytes in Healing: Wounds and other Pathologies. Int. J. Mol. Sci. 2017, 18, 1129.

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