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Int. J. Mol. Sci. 2017, 18(6), 1124; doi:10.3390/ijms18061124

Translational Development and Application of (1→3)-β-d-Glucan for Diagnosis and Therapeutic Monitoring of Invasive Mycoses

1
Division of General Internal Medicine, Weill Cornell Medicine of Cornell University, New York, NY 10065, USA
2
Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, NY 10065, USA
3
Departments of Pediatrics, and Microbiology & Immunology, Weill Cornell Medicine, New York, NY 10065, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Vaclav Vetvicka
Received: 14 April 2017 / Revised: 9 May 2017 / Accepted: 16 May 2017 / Published: 24 May 2017
(This article belongs to the Special Issue Glucan: New Perspectives on Biochemistry and Application)
View Full-Text   |   Download PDF [241 KB, uploaded 24 May 2017]   |  

Abstract

Early diagnosis and prompt initiation of appropriate antimicrobial therapy are crucial steps in the management of patients with invasive fungal infections. However, the diagnosis of invasive mycoses remains a major challenge in clinical practice, because presenting symptoms may be subtle and non-invasive diagnostic assays often lack sensitivity and specificity. Diagnosis is often expressed on a scale of probability (proven, probable and possible) based on a constellation of imaging findings, microbiological tools and histopathology, as there is no stand-alone assay for diagnosis. Recent data suggest that the carbohydrate biomarker (1→3)-β-d-glucan may be useful in both the diagnosis and therapeutic monitoring of invasive fungal infections due to some yeasts, molds, and dimorphic fungi. In this paper, we review recent advances in the use of (1→3)-β-d-glucan to monitor clinical response to antifungal therapy and explore how this assay may be used in the future. View Full-Text
Keywords: antigenemia; pulmonary aspergillosis; ventriculitis; meningitis; candidiasis antigenemia; pulmonary aspergillosis; ventriculitis; meningitis; candidiasis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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McCarthy, M.W.; Petraitiene, R.; Walsh, T.J. Translational Development and Application of (1→3)-β-d-Glucan for Diagnosis and Therapeutic Monitoring of Invasive Mycoses. Int. J. Mol. Sci. 2017, 18, 1124.

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