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Int. J. Mol. Sci. 2017, 18(6), 1126; doi:10.3390/ijms18061126

The Peroxisome-Mitochondria Connection: How and Why?

1
Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine, KU Leuven, University of Leuven, 3000 Leuven, Belgium
2
Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 3K7, Canada
*
Author to whom correspondence should be addressed.
Received: 27 April 2017 / Revised: 15 May 2017 / Accepted: 20 May 2017 / Published: 24 May 2017
(This article belongs to the Special Issue Mitochondria Crosstalks with other Organelles in Pathophysiology)
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Abstract

Over the past decades, peroxisomes have emerged as key regulators in overall cellular lipid and reactive oxygen species metabolism. In mammals, these organelles have also been recognized as important hubs in redox-, lipid-, inflammatory-, and innate immune-signaling networks. To exert these activities, peroxisomes must interact both functionally and physically with other cell organelles. This review provides a comprehensive look of what is currently known about the interconnectivity between peroxisomes and mitochondria within mammalian cells. We first outline how peroxisomal and mitochondrial abundance are controlled by common sets of cis- and trans-acting factors. Next, we discuss how peroxisomes and mitochondria may communicate with each other at the molecular level. In addition, we reflect on how these organelles cooperate in various metabolic and signaling pathways. Finally, we address why peroxisomes and mitochondria have to maintain a healthy relationship and why defects in one organelle may cause dysfunction in the other. Gaining a better insight into these issues is pivotal to understanding how these organelles function in their environment, both in health and disease. View Full-Text
Keywords: peroxisomes; mitochondria; fatty acid oxidation; reactive oxygen species; interorganelle crosstalk; organelle abundance; organelle dysfunction; human disease peroxisomes; mitochondria; fatty acid oxidation; reactive oxygen species; interorganelle crosstalk; organelle abundance; organelle dysfunction; human disease
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fransen, M.; Lismont, C.; Walton, P. The Peroxisome-Mitochondria Connection: How and Why? Int. J. Mol. Sci. 2017, 18, 1126.

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