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Int. J. Mol. Sci. 2017, 18(6), 1108; doi:10.3390/ijms18061108

Epigenetic Strategies to Boost Cancer Immunotherapies

CNIO-Lilly Epigenetics Laboratory, Spanish National Cancer Research Center (CNIO), C/Melchor Fernández Almagro, 3. 28029 Madrid, Spain
Academic Editor: Nicoletta Sacchi
Received: 27 April 2017 / Revised: 18 May 2017 / Accepted: 19 May 2017 / Published: 23 May 2017
(This article belongs to the Special Issue Cancer Epigenetics)
View Full-Text   |   Download PDF [1421 KB, uploaded 23 May 2017]   |  

Abstract

Recently, immunotherapeutic approaches have shown impressive responses in a subset of cancer patients. However, the rate of success is low and a large percentage of treated patients do not experience clinical benefits. Therefore, additional strategies are needed to improve responses and select responsive patients. Emerging data suggest that epigenetic drugs can improve the responses to immunotherapy. Understanding the mechanisms of resistance to immunotherapy and the epigenetic events that take place during immune evasion is critical to providing a rational combined use of immunotherapies and epigenetic drugs. This review focuses in the epigenetic mechanisms involved in the responses to immunotherapy and how current drugs that target epigenetic regulators impact on them. View Full-Text
Keywords: immunotherapy; cancer; epigenetics immunotherapy; cancer; epigenetics
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Barrero, M.J. Epigenetic Strategies to Boost Cancer Immunotherapies. Int. J. Mol. Sci. 2017, 18, 1108.

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