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Int. J. Mol. Sci. 2017, 18(5), 956; doi:10.3390/ijms18050956

Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing

1
Tissue Repair and Translational Physiology Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia
2
School of Biomedical Science, Faculty of Health, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia
3
Wound Management Innovation Cooperative Research Centre, 25 Donkin, West End, Queensland 4101 Australia
4
Institute of Medical Biology—Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Allison Cowin
Received: 21 March 2017 / Revised: 19 April 2017 / Accepted: 27 April 2017 / Published: 1 May 2017
(This article belongs to the Special Issue Wound Repair and Regeneration)
View Full-Text   |   Download PDF [3045 KB, uploaded 5 May 2017]   |  

Abstract

Extracellular vesicles (EVs) are membrane-enclosed vesicles that are released into the extracellular environment by various cell types, which can be classified as apoptotic bodies, microvesicles and exosomes. EVs have been shown to carry DNA, small RNAs, proteins and membrane lipids which are derived from the parental cells. Recently, several studies have demonstrated that EVs can regulate many biological processes, such as cancer progression, the immune response, cell proliferation, cell migration and blood vessel tube formation. This regulation is achieved through the release and transport of EVs and the transfer of their parental cell-derived molecular cargo to recipient cells. This thereby influences various physiological and sometimes pathological functions within the target cells. While intensive investigation of EVs has focused on pathological processes, the involvement of EVs in normal wound healing is less clear; however, recent preliminarily investigations have produced some initial insights. This review will provide an overview of EVs and discuss the current literature regarding the role of EVs in wound healing, especially, their influence on coagulation, cell proliferation, migration, angiogenesis, collagen production and extracellular matrix remodelling. View Full-Text
Keywords: wound healing; proliferation; migration; angiogenesis; extracellular membrane vesicles; microvesicles; apoptotic bodies; exosomes; endothelial cells; keratinocytes wound healing; proliferation; migration; angiogenesis; extracellular membrane vesicles; microvesicles; apoptotic bodies; exosomes; endothelial cells; keratinocytes
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MDPI and ACS Style

Than, U.T.T.; Guanzon, D.; Leavesley, D.; Parker, T. Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing. Int. J. Mol. Sci. 2017, 18, 956.

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