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Int. J. Mol. Sci. 2017, 18(5), 911; doi:10.3390/ijms18050911

Radiation and Thyroid Cancer

1
Department of Pharmaceutical Science, University of Perugia, 06123 Perugia, Italy
2
Research Center and Analysis Laboratory CRABiON, 06073 Perugia, Italy
3
Department of Clinical and Biological Sciences, University of Udine, 33100 Udine, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Daniela Gabriele Grimm and Sanjay K. Srivastava
Received: 17 February 2017 / Revised: 11 April 2017 / Accepted: 24 April 2017 / Published: 26 April 2017
(This article belongs to the Special Issue Current Knowledge in Thyroid Cancer—From Bench to Bedside)
View Full-Text   |   Download PDF [844 KB, uploaded 27 April 2017]   |  

Abstract

Radiation-induced damage is a complex network of interlinked signaling pathways, which may result in apoptosis, cell cycle arrest, DNA repair, and cancer. The development of thyroid cancer in response to radiation, from nuclear catastrophes to chemotherapy, has long been an object of study. A basic overview of the ionizing and non-ionizing radiation effects of the sensitivity of the thyroid gland on radiation and cancer development has been provided. In this review, we focus our attention on experiments in cell cultures exposed to ionizing radiation, ultraviolet light, and proton beams. Studies on the involvement of specific genes, proteins, and lipids are also reported. This review also describes how lipids are regulated in response to the radiation-induced damage and how they are involved in thyroid cancer etiology, invasion, and migration and how they can be used as both diagnostic markers and drug targets. View Full-Text
Keywords: radiation; thyroid cancer; cancer genes; lipid metabolism radiation; thyroid cancer; cancer genes; lipid metabolism
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Albi, E.; Cataldi, S.; Lazzarini, A.; Codini, M.; Beccari, T.; Ambesi-Impiombato, F.S.; Curcio, F. Radiation and Thyroid Cancer. Int. J. Mol. Sci. 2017, 18, 911.

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