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Int. J. Mol. Sci. 2017, 18(5), 1068; doi:10.3390/ijms18051068

The Role of Phytochemicals in the Inflammatory Phase of Wound Healing

1
Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
2
Department of Surgery, University of Toronto, Toronto, ON M5S 1A8, Canada
3
Department of Laboratory Medicine and Pathobiology (LMP), University of Toronto, Toronto, ON M5S 1A8, Canada
4
Sunnybrook Research Institute, Sunnybrook Health Science Centre, Toronto, ON M5S 1A8, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Woo-Sik Jeong
Received: 30 March 2017 / Revised: 10 May 2017 / Accepted: 13 May 2017 / Published: 16 May 2017
(This article belongs to the Special Issue Nutrients and Phytochemicals for Skin Health)
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Abstract

Historically, plant-based products have been the basis of medicine since before the advent of modern Western medicine. Wound dressings made of honey, curcumin and other phytochemical-rich compounds have been traditionally used. Recently, the mechanisms behind many of these traditional therapies have come to light. In this review, we show that in the context of wound healing, there is a global theme of anti-inflammatory and antioxidant phytochemicals in traditional medicine. Although promising, we discuss the limitations of using some of these phytochemicals in order to warrant more research, ideally in randomized clinical trial settings. View Full-Text
Keywords: phytochemicals; inflammatory cytokines; wound healing; burns; chronic wounds; wound infections; hypertrophic scarring; curcumin; honey; Terminalia phytochemicals; inflammatory cytokines; wound healing; burns; chronic wounds; wound infections; hypertrophic scarring; curcumin; honey; Terminalia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shah, A.; Amini-Nik, S. The Role of Phytochemicals in the Inflammatory Phase of Wound Healing. Int. J. Mol. Sci. 2017, 18, 1068.

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