Next Article in Journal
Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases
Next Article in Special Issue
Engineering Exosomes for Cancer Therapy
Previous Article in Journal
Characterization of Copy Number Variation’s Potential Role in Marek’s Disease
Previous Article in Special Issue
Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(5), 1022; doi:10.3390/ijms18051022

Mesenchymal Stem Cell Derived Extracellular Vesicles: A Role in Hematopoietic Transplantation?

1
Laboratory of Preclinical and Translational Research, IRCCS—Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture, Italy
2
CEINGE Biotecnologie Avanzate s.c.a r.l., 80147 Naples, Italy
3
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80138 Napoli, Italy
4
Scientific Direction, IRCCS—Referral Cancer Center of Basilicata (CROB), 85028 Rionero in Vulture, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas Ritter
Received: 3 April 2017 / Revised: 4 May 2017 / Accepted: 4 May 2017 / Published: 9 May 2017
View Full-Text   |   Download PDF [1350 KB, uploaded 9 May 2017]   |  

Abstract

Mesenchymal stem cells (MSCs) are a heterogeneous cellular population containing different progenitors able to repair tissues, support hematopoiesis, and modulate immune and inflammatory responses. Several clinical trials have used MSCs in allogeneic hematopoietic stem cell transplantation (allo-HSCT) to prevent hematopoietic stem cell (HSC) engraftment failure, reduce aplasia post chemotherapy, and to control graft versus host disease (GvHD). The efficacy of MSCs is linked to their immune suppressive and anti-inflammatory properties primarily due to the release of soluble factors. Recent studies indicate that most of these effects are mediated by extracellular vesicles (EVs). MSC-EVs have therefore therapeutic effects in regenerative medicine, tumor inhibition, and immune-regulation. MSC-EVs may offer specific advantages for patient safety, such as lower propensity to trigger innate and adaptive immune responses. It has been also shown that MSC-EVs can prevent or treat acute-GvHD by modulating the immune-response and, combined with HSCs, may contribute to the hematopoietic microenvironment reconstitution. Finally, MSC-EVs may provide a new potential therapeutic option (e.g., transplantation, gene therapy) for different diseases, particularly hematological malignancies. In this review, we will describe MSC and MSC-EVs role in improving allo-HSCT procedures and in treating GvHD. View Full-Text
Keywords: mesenchymal stem cells; hematopoietic stem cell transplantation; graft versus host disease; extracellular vesicles mesenchymal stem cells; hematopoietic stem cell transplantation; graft versus host disease; extracellular vesicles
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

De Luca, L.; Trino, S.; Laurenzana, I.; Lamorte, D.; Caivano, A.; Del Vecchio, L.; Musto, P. Mesenchymal Stem Cell Derived Extracellular Vesicles: A Role in Hematopoietic Transplantation? Int. J. Mol. Sci. 2017, 18, 1022.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top