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Int. J. Mol. Sci. 2017, 18(5), 1024; doi:10.3390/ijms18051024

Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases

Department of Chemistry, Center for Diagnostics and Therapeutics (CDT), Georgia State University, Atlanta, GA 30303, USA
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Academic Editor: ChulHee Kang
Received: 11 February 2017 / Revised: 28 April 2017 / Accepted: 1 May 2017 / Published: 10 May 2017
(This article belongs to the Special Issue Calcium Regulation and Sensing)
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Abstract

The flow of intracellular calcium (Ca2+) is critical for the activation and regulation of important biological events that are required in living organisms. As the major Ca2+ repositories inside the cell, the endoplasmic reticulum (ER) and the sarcoplasmic reticulum (SR) of muscle cells are central in maintaining and amplifying the intracellular Ca2+ signal. The morphology of these organelles, along with the distribution of key calcium-binding proteins (CaBPs), regulatory proteins, pumps, and receptors fundamentally impact the local and global differences in Ca2+ release kinetics. In this review, we will discuss the structural and morphological differences between the ER and SR and how they influence localized Ca2+ release, related diseases, and the need for targeted genetically encoded calcium indicators (GECIs) to study these events. View Full-Text
Keywords: calcium signaling; endoplasmic reticulum; sarcoplasmic reticulum; RyR; IP3R; SERCA pump; JP45; calsequestrin; GECI calcium signaling; endoplasmic reticulum; sarcoplasmic reticulum; RyR; IP3R; SERCA pump; JP45; calsequestrin; GECI
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Reddish, F.N.; Miller, C.L.; Gorkhali, R.; Yang, J.J. Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases. Int. J. Mol. Sci. 2017, 18, 1024.

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