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Int. J. Mol. Sci. 2017, 18(4), 891; doi:10.3390/ijms18040891

Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy

1
Laboratorio de Biología del Desarrollo, UD de Bioquímica y Biología Molecular and Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna, Av. Astrofísico Sánchez s/n., 38206 La Laguna, Spain
2
CNR—National Research Council, Institute of Endocrinology and Experimental Oncology (IEOS), Via Sergio Pansini 5, 80131 Naples, Italy
3
Service of Medical Oncology, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
4
Service of Medical Oncology, Hospiten® Hospitals, 38001 Santa Cruz de Tenerife, Spain
5
Service of Pathology, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
6
Department of Pathology, Hospiten® Hospitals, 38001 Santa Cruz de Tenerife, Spain
7
School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH Guildford, UK
8
Center of Excellence in Genomic Medicine Research (CEGMR), King Fahd Medical Research Center (KFMRC), Faculty of Applied Medical Sciences, King AbdulAziz University, 21589 Jeddah, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editor: Peter J.K. Kuppen
Received: 22 February 2017 / Revised: 15 April 2017 / Accepted: 19 April 2017 / Published: 22 April 2017
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Abstract

Scaffold proteins play pivotal roles in the regulation of signaling pathways, integrating external and internal stimuli to various cellular outputs. We report the pattern of cellular and subcellular expression of scaffoldins angiomotin-like 2 (AmotL2), FK506 binding protein 5 (FKBP51) and IQ motif containing GTPase-activating protein 1 (IQGAP1) in colorectal cancer (CRC) and metastases in liver resected after oxaliplatin-based chemotherapy (CT). Positive immunostaining for the three scaffoldins was found in most cells in healthy colon, tumor, healthy liver and metastasized liver. The patterns of expression of AmotL2, FKBP51 and IQGAP1 show the greatest variability in immune system cells and neurons and glia cells and the least in blood vessel cells. The simultaneous subcellular localization in tumor cells and other cell types within the tumor suggest an involvement of these three scaffoldins in cancer biology, including a role in Epithelial Mesenchymal Transition. The display in differential localization and quantitative expression of AmotL2, FKBP51, and IQGAP1 could be used as biomarkers for more accurate tumor staging and as potential targets for anti-cancer therapeutics by blocking or slowing down their interconnecting functions. Tough further research needs to be done in order to improve these assessments. View Full-Text
Keywords: colorectal cancer; scaffold proteins; AmotL2; FKBP51; IQGAP1; metastasized liver; FOLFOX; oxaliplatin; pericytes; telocytes colorectal cancer; scaffold proteins; AmotL2; FKBP51; IQGAP1; metastasized liver; FOLFOX; oxaliplatin; pericytes; telocytes
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MDPI and ACS Style

Rotoli, D.; Morales, M.; Ávila, J.; Maeso, M.C.; García, M.P.; Mobasheri, A.; Martín-Vasallo, P. Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy. Int. J. Mol. Sci. 2017, 18, 891.

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