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Int. J. Mol. Sci. 2017, 18(4), 866; doi:10.3390/ijms18040866

Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis

1
Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Yanagido, Gifu 501-1193, Japan
2
Department of Surgical Oncology, Gifu University Graduate School of Medicine, Yanagido, Gifu 501-1193, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Peter J. K. Kuppen
Received: 13 March 2017 / Revised: 12 April 2017 / Accepted: 17 April 2017 / Published: 19 April 2017
View Full-Text   |   Download PDF [913 KB, uploaded 19 April 2017]   |  

Abstract

Overweight is believed to be associated with colorectal cancer risk. Adipose tissue is loose connective tissue composed of adipocytes. It is now recognized as a major endocrine organ, secreting humoral factors collectively called adipokines. Aberrant hormonal systems consisting of modulated adipokines and their receptors are thought to play a role in colorectal carcinogenesis and cancer progression in obese conditions. However, it is still unclear whether and how each adipokine relates to colorectal carcinogenesis. Notably, a couple of molecules that were initially proposed to be obesity-related adipokines were disqualified by subsequent studies. The adipokines, adiponectin, and intelectin-1 (also known as omentin-1), whose levels are decreased in obesity, act as tumor suppressor factors in various cancers. Numerous studies have demonstrated a link between the insufficient expression and function of adiponectin and its receptor, T-cadherin, in colorectal carcinogenesis. Moreover, our recent study indicated that loss of TMEM207, which is critical for the proper processing of intelectin-1 in the colon mucosa, leads to insufficient intelectin-1 production, thus participating in colorectal carcinogenesis. Here, we discuss the recent understanding of the role of adipokines in colorectal carcinogenesis and subsequently describe the potent tumor suppressor roles of intelectin-1 and TMEM207 in colorectal cancer. View Full-Text
Keywords: adipokines; obesity; colorectal cancer; adiponectin; intelectin-1; TMEM207 adipokines; obesity; colorectal cancer; adiponectin; intelectin-1; TMEM207
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Kawashima, K.; Maeda, K.; Saigo, C.; Kito, Y.; Yoshida, K.; Takeuchi, T. Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis. Int. J. Mol. Sci. 2017, 18, 866.

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