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Int. J. Mol. Sci. 2017, 18(4), 866; doi:10.3390/ijms18040866

Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis

Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Yanagido, Gifu 501-1193, Japan
Department of Surgical Oncology, Gifu University Graduate School of Medicine, Yanagido, Gifu 501-1193, Japan
Author to whom correspondence should be addressed.
Academic Editor: Peter J. K. Kuppen
Received: 13 March 2017 / Revised: 12 April 2017 / Accepted: 17 April 2017 / Published: 19 April 2017
View Full-Text   |   Download PDF [913 KB, uploaded 19 April 2017]   |  


Overweight is believed to be associated with colorectal cancer risk. Adipose tissue is loose connective tissue composed of adipocytes. It is now recognized as a major endocrine organ, secreting humoral factors collectively called adipokines. Aberrant hormonal systems consisting of modulated adipokines and their receptors are thought to play a role in colorectal carcinogenesis and cancer progression in obese conditions. However, it is still unclear whether and how each adipokine relates to colorectal carcinogenesis. Notably, a couple of molecules that were initially proposed to be obesity-related adipokines were disqualified by subsequent studies. The adipokines, adiponectin, and intelectin-1 (also known as omentin-1), whose levels are decreased in obesity, act as tumor suppressor factors in various cancers. Numerous studies have demonstrated a link between the insufficient expression and function of adiponectin and its receptor, T-cadherin, in colorectal carcinogenesis. Moreover, our recent study indicated that loss of TMEM207, which is critical for the proper processing of intelectin-1 in the colon mucosa, leads to insufficient intelectin-1 production, thus participating in colorectal carcinogenesis. Here, we discuss the recent understanding of the role of adipokines in colorectal carcinogenesis and subsequently describe the potent tumor suppressor roles of intelectin-1 and TMEM207 in colorectal cancer. View Full-Text
Keywords: adipokines; obesity; colorectal cancer; adiponectin; intelectin-1; TMEM207 adipokines; obesity; colorectal cancer; adiponectin; intelectin-1; TMEM207

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kawashima, K.; Maeda, K.; Saigo, C.; Kito, Y.; Yoshida, K.; Takeuchi, T. Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis. Int. J. Mol. Sci. 2017, 18, 866.

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