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Int. J. Mol. Sci. 2017, 18(4), 799; doi:10.3390/ijms18040799

ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer

1
Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea
2
Department of Gastroenterology and Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Kumiko Ui-Tei
Received: 4 March 2017 / Revised: 4 April 2017 / Accepted: 6 April 2017 / Published: 11 April 2017
(This article belongs to the Special Issue microRNA Regulation 2017)
View Full-Text   |   Download PDF [1117 KB, uploaded 11 April 2017]   |  

Abstract

The evolution of cancer cells is believed to be dependent on genetic or epigenetic alterations. However, this concept has recently been challenged by another mode of nucleotide alteration, RNA editing, which is frequently up-regulated in cancer. RNA editing is a biochemical process in which either Adenosine or Cytosine is deaminated by a group of RNA editing enzymes including ADAR (Adenosine deaminase; RNA specific) or APOBEC3B (Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3B). The result of RNA editing is usually adenosine to inosine (A-to-I) or cytidine to uridine (C-to-U) transition, which can affect protein coding, RNA stability, splicing and microRNA-target interactions. The functional impact of these alterations is largely unclear and is a subject of extensive research. In the present review, we will specifically focus on the influence of ADARs on carcinogenesis via the regulation of microRNA processing and functioning. This follows a brief review of the current knowledge of properties of ADAR enzyme, RNA editing, and microRNA processing. View Full-Text
Keywords: ADAR (Adenosine deaminase; RNA specific); UTR (untranslated region); NGS (Next Generation Sequencing) ADAR (Adenosine deaminase; RNA specific); UTR (untranslated region); NGS (Next Generation Sequencing)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cho, C.J.; Myung, S.-J.; Chang, S. ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer. Int. J. Mol. Sci. 2017, 18, 799.

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