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Int. J. Mol. Sci. 2017, 18(4), 745; doi:10.3390/ijms18040745

The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical Application

Institute for Translational Medicine, Qingdao University, Qingdao 266021, China
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Authors to whom correspondence should be addressed.
Academic Editors: Kumiko Ui-Tei, Y-h. Taguchi and Andreas Keller
Received: 26 January 2017 / Revised: 22 March 2017 / Accepted: 27 March 2017 / Published: 31 March 2017
(This article belongs to the Special Issue microRNA Regulation 2017)
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Abstract

MicroRNAs (miRNAs) are a class of small single-stranded and highly conserved non-coding RNAs, which are closely linked to cardiac disorders such as myocardial infarction (MI), cardiomyocyte hypertrophy, and heart failure. A growing number of studies have demonstrated that miRNAs determine the fate of the heart by regulating cardiac cell death and regeneration after MI. A deep understanding of the pathophysiology of miRNA dependent regulatory pathways in these processes is required. The role of miRNAs as diagnostic, prognostic, and therapeutic targets also needs to be explored in order to utilize them in clinical settings. This review summarizes the role of miRNAs in myocardial infarction and focuses mainly on their influence on cardiomyocyte regeneration and cell death including apoptosis, necrosis, and autophagy. In addition, the targets of pro- and anti-MI miRNAs are comparatively described. In particular, the possibilities of miRNA-based diagnostic and therapeutic strategies for myocardial infarction are discussed in this review. View Full-Text
Keywords: microRNAs; myocardial infarction; myocardial cell death; cardiomyocyte regeneration; clinical application microRNAs; myocardial infarction; myocardial cell death; cardiomyocyte regeneration; clinical application
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Sun, T.; Dong, Y.-H.; Du, W.; Shi, C.-Y.; Wang, K.; Tariq, M.-A.; Wang, J.-X.; Li, P.-F. The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical Application. Int. J. Mol. Sci. 2017, 18, 745.

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