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Int. J. Mol. Sci. 2017, 18(4), 790; doi:10.3390/ijms18040790

Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia

1
Laboratory for Neuroscience of Mental Disorders “Elena Pessino”, Canis Majoris Foundation, Madrid Science Park, 28049 Madrid, Spain
2
Department of Medicine and Medical Specialties, Faculty of Medicine, University of Alcalá, Universitary Campus, A2-Km 33.6, Alcalá de Henares, 28805 Madrid, Spain
3
Department of Psychiatry, Ramón y Cajal Hospital, IRYCIS, Ctra Colmenar Km 9.1, 28034 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Yong-Ku Kim
Received: 25 February 2017 / Revised: 23 March 2017 / Accepted: 4 April 2017 / Published: 7 April 2017
View Full-Text   |   Download PDF [256 KB, uploaded 19 April 2017]

Abstract

Schizophrenia is a complex mental disorder whose causes are still far from being known. Although researchers have focused on genetic or environmental contributions to the disease, we still lack a scientific framework that joins molecular and clinical findings. Epigenetic can explain how environmental variables may affect gene expression without modifying the DNA sequence. In fact, neuroepigenomics represents an effort to unify the research available on the molecular pathology of mental diseases, which has been carried out through several approaches ranging from interrogating single DNA methylation events and hydroxymethylation patterns, to epigenome-wide association studies, as well as studying post-translational modifications of histones, or nucleosomal positioning. The high dependence on tissues with epigenetic marks compels scientists to refine their sampling procedures, and in this review, we will focus on findings obtained from brain tissue. Despite our efforts, we still need to refine our hypothesis generation process to obtain real knowledge from a neuroepigenomic framework, to avoid the creation of more noise on this innovative point of view; this may help us to definitively unravel the molecular pathology of severe mental illnesses, such as schizophrenia. View Full-Text
Keywords: schizophrenia; human brain; epigenetic; neuroepigenome; molecular pathology schizophrenia; human brain; epigenetic; neuroepigenome; molecular pathology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cariaga-Martinez, A.; Alelú-Paz, R. Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia. Int. J. Mol. Sci. 2017, 18, 790.

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