Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia
AbstractSchizophrenia is a complex mental disorder whose causes are still far from being known. Although researchers have focused on genetic or environmental contributions to the disease, we still lack a scientific framework that joins molecular and clinical findings. Epigenetic can explain how environmental variables may affect gene expression without modifying the DNA sequence. In fact, neuroepigenomics represents an effort to unify the research available on the molecular pathology of mental diseases, which has been carried out through several approaches ranging from interrogating single DNA methylation events and hydroxymethylation patterns, to epigenome-wide association studies, as well as studying post-translational modifications of histones, or nucleosomal positioning. The high dependence on tissues with epigenetic marks compels scientists to refine their sampling procedures, and in this review, we will focus on findings obtained from brain tissue. Despite our efforts, we still need to refine our hypothesis generation process to obtain real knowledge from a neuroepigenomic framework, to avoid the creation of more noise on this innovative point of view; this may help us to definitively unravel the molecular pathology of severe mental illnesses, such as schizophrenia. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Cariaga-Martinez, A.; Alelú-Paz, R. Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia. Int. J. Mol. Sci. 2017, 18, 790.
Cariaga-Martinez A, Alelú-Paz R. Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia. International Journal of Molecular Sciences. 2017; 18(4):790.Chicago/Turabian Style
Cariaga-Martinez, Ariel; Alelú-Paz, Raúl. 2017. "Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia." Int. J. Mol. Sci. 18, no. 4: 790.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.