Next Article in Journal
Gene-Diet Interaction and Precision Nutrition in Obesity
Next Article in Special Issue
Genetics of Congenital Anomalies of the Kidney and Urinary Tract: The Current State of Play
Previous Article in Journal
Prp19 Arrests Cell Cycle via Cdc5L in Hepatocellular Carcinoma Cells
Previous Article in Special Issue
Developmental Origins of Chronic Kidney Disease: Should We Focus on Early Life?
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(4), 783; doi:10.3390/ijms18040783

Emerging Roles of IL-33/ST2 Axis in Renal Diseases

1
Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
2
Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Alan Parrish
Received: 17 March 2017 / Revised: 29 March 2017 / Accepted: 5 April 2017 / Published: 7 April 2017
(This article belongs to the Special Issue Advances in Chronic Kidney Disease 2017)
View Full-Text   |   Download PDF [1009 KB, uploaded 7 April 2017]   |  

Abstract

Renal diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), have a great impact on health care systems worldwide. Similar to cardiovascular diseases, renal diseases are inflammatory diseases involving a variety of cytokines. Primary causes of renal injury include ischemia, uremic toxins, bacteremia, or nephrotoxicity. Inflammation represents an important component following kidney injury. Interleukin (IL)-33 is a member of the IL-1 cytokine family, which is widely expressed in epithelial barrier tissues and endothelial cells, and mediates both tissue inflammation and repair responses. IL-33 is released as a nuclear alarmin in response to tissue damage and triggers innate and adaptive immune responses by binding to its receptor, suppression of tumorigenicity 2 (ST2). Recent evidence from clinical and experimental animal studies indicates that the IL-33/ST2 axis is involved in the pathogenesis of CKD, renal graft injury, systemic lupus nephritis, and AKI. In this review, we discuss the pathological and tissue reparative roles of the IL-33/ST2 pathway in different types of renal diseases. View Full-Text
Keywords: interleukin-33; chronic renal disease; acute renal injury; inflammation interleukin-33; chronic renal disease; acute renal injury; inflammation
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chen, W.-Y.; Li, L.-C.; Yang, J.-L. Emerging Roles of IL-33/ST2 Axis in Renal Diseases. Int. J. Mol. Sci. 2017, 18, 783.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top