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Int. J. Mol. Sci. 2017, 18(4), 787; doi:10.3390/ijms18040787

Gene-Diet Interaction and Precision Nutrition in Obesity

1
and
1,2,*
1
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
2
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Lynnette Ferguson and Virginia R. Parslow
Received: 22 February 2017 / Revised: 30 March 2017 / Accepted: 3 April 2017 / Published: 7 April 2017
(This article belongs to the Special Issue Gene-Diet Interactions in Chronic Diseases)
View Full-Text   |   Download PDF [246 KB, uploaded 7 April 2017]

Abstract

The rapid rise of obesity during the past decades has coincided with a profound shift of our living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical inactivity. Genetic predisposition to obesity may have interacted with such an obesogenic environment in determining the obesity epidemic. Growing studies have found that changes in adiposity and metabolic response to low-calorie weight loss diets might be modified by genetic variants related to obesity, metabolic status and preference to nutrients. This review summarized data from recent studies of gene-diet interactions, and discussed integration of research of metabolomics and gut microbiome, as well as potential application of the findings in precision nutrition. View Full-Text
Keywords: gene-diet interactions; weight loss; obesity gene-diet interactions; weight loss; obesity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Heianza, Y.; Qi, L. Gene-Diet Interaction and Precision Nutrition in Obesity. Int. J. Mol. Sci. 2017, 18, 787.

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