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Int. J. Mol. Sci. 2017, 18(4), 778; doi:10.3390/ijms18040778

Prp19 Arrests Cell Cycle via Cdc5L in Hepatocellular Carcinoma Cells

1
Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai 200032, China
2
Key Laboratory of Medical Molecular Virology, Shanghai Medical College of Fudan University, Shanghai 200032, China
3
Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Akihiro Tamori
Received: 16 January 2017 / Revised: 23 March 2017 / Accepted: 31 March 2017 / Published: 7 April 2017
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Pre-mRNA processing factor 19 (Prp19) is involved in many cellular events including pre-mRNA processing and DNA damage response. Recently, it has been identified as a candidate oncogene in hepatocellular carcinoma (HCC). However, the role of Prp19 in tumor biology is still elusive. Here, we reported that Prp19 arrested cell cycle in HCC cells via regulating G2/M transition. Mechanistic insights revealed that silencing Prp19 inhibited the expression of cell division cycle 5-like (Cdc5L) via repressing the translation of Cdc5L mRNA and facilitating lysosome-mediated degradation of Cdc5L in HCC cells. Furthermore, we found that silencing Prp19 induced cell cycle arrest could be partially resumed by overexpressing Cdc5L. This work implied that Prp19 participated in mitotic progression and thus could be a promising therapeutic target of HCC. View Full-Text
Keywords: pre-mRNA processing factor 19; cell division cycle 5-like; cell cycle; translation; repressing the translation of mRNA; lysosome-mediated degradation pre-mRNA processing factor 19; cell division cycle 5-like; cell cycle; translation; repressing the translation of mRNA; lysosome-mediated degradation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Huang, R.; Xue, R.; Qu, D.; Yin, J.; Shen, X.-Z. Prp19 Arrests Cell Cycle via Cdc5L in Hepatocellular Carcinoma Cells. Int. J. Mol. Sci. 2017, 18, 778.

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