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Int. J. Mol. Sci. 2017, 18(3), 613; doi:10.3390/ijms18030613

Strawberry-Tree Honey Induces Growth Inhibition of Human Colon Cancer Cells and Increases ROS Generation: A Comparison with Manuka Honey

1
Department of Clinical Sciences, Faculty of Medicine, Polytechnic University of Marche, via Ranieri 65, Ancona 60131, Italy
2
Department of Biomedical Sciences and Public Health, Faculty of Medicine, Polytechnic University of Marche, via Ranieri 65, Ancona 60131, Italy
3
Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Centre, University of Granada, Armilla 18100, Spain
4
Department of Chemistry and Pharmacy, University of Sassari, via Vienna 2, Sassari 07100, Italy
5
Centre for Nutrition & Health, European University of the Atlantic, Santander 39011, Spain
6
Department of Clinical Sciences, Faculty of Medicine, Polytechnic University of Marche, via Ranieri 65, Ancona 60131, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 19 December 2016 / Revised: 10 February 2017 / Accepted: 3 March 2017 / Published: 11 March 2017
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Abstract

Honey is a natural product known to modulate several biological activities including cancer. The aim of the present study was to examine the phytochemical content and the antioxidant activity of Strawberry tree (Arbutus unedo) honey (STH) and its cytotoxic properties against human colon adenocarcinoma (HCT-116) and metastatic (LoVo) cell lines in comparison with Manuka (Leptospermum scoparium) honey (MH). Several unifloral STH and MH were analyzed for their phenolic, flavonoid, amino acid and protein contents, as well as their radical scavenging activities. STH from the Berchidda area showed the highest amount of phenolic, flavonoid, amino acid and protein content, and antioxidant capacity compared to MH. Both STH and MH induced cytotoxicity and cell death in a dose- and time-dependent manner in HCT-116 and LoVo cells, with less toxicity on non-cancer cells. Compared to MH, STH showed more effect at lower concentrations on HCT-116 and LoVo cells. In addition, both honeys increased intracellular reactive oxygen species (ROS) generation. In HCT-116 cells, STH and MH induced similar ROS production but in LoVo cells STH induced a higher percentage of ROS compared to MH. Our results indicate that STH and MH can induce cell growth inhibition and ROS generation in colon adenocarcinoma and metastatic cells, which could be due to the presence of phytochemicals with antioxidant properties. These preliminary results are interesting and suggest a potential chemopreventive action which could be useful for further studies in order to develop chemopreventive agents for colon cancer. View Full-Text
Keywords: Manuka honey; strawberry tree honey; polyphenols; antioxidant activity; cytotoxicity; reactive oxygen species; colon cancer Manuka honey; strawberry tree honey; polyphenols; antioxidant activity; cytotoxicity; reactive oxygen species; colon cancer
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Afrin, S.; Forbes-Hernandez, T.Y.; Gasparrini, M.; Bompadre, S.; Quiles, J.L.; Sanna, G.; Spano, N.; Giampieri, F.; Battino, M. Strawberry-Tree Honey Induces Growth Inhibition of Human Colon Cancer Cells and Increases ROS Generation: A Comparison with Manuka Honey. Int. J. Mol. Sci. 2017, 18, 613.

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