Sex-Dependent Effects of HO-1 Deletion from Adipocytes in Mice
AbstractInduction of heme oxygenase-1 (HO-1) has been demonstrated to decrease body weight and improve insulin sensitivity in several models of obesity in rodents. To further study the role of HO-1 in adipose tissue, we created an adipose-specific HO-1 knockout mouse model. Male and female mice were fed either a control or a high-fat diet for 30 weeks. Body weights were measured weekly and body composition, fasting blood glucose and insulin levels were determined every six weeks. Adipocyte-specific knockout of HO-1 had no significant effect on body weight in mice fed a high-fat diet but increased body weight in female mice fed a normal-fat diet. Although body weights were not different in females fed a high fat diet, loss of HO-1 in adipocytes resulted in significant alterations in body composition. Adipose-specific HO-1 knockout resulted in increased fasting hyperglycemia and insulinemia in female but not male mice on both diets. Adipose-specific knockout of HO-1 resulted in a significant loss of HO activity and a decrease in the protein levels of adiponectin in adipose tissue. These results demonstrate that loss of HO-1 in adipocytes has greater effects on body fat and fasting hyperglycemia in a sex-dependent fashion and that expression of HO-1 in adipose tissue may have a greater protective role in females as compared to males. View Full-Text
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Hosick, P.A.; Weeks, M.F.; Hankins, M.W.; Moore, K.H.; Stec, D.E. Sex-Dependent Effects of HO-1 Deletion from Adipocytes in Mice. Int. J. Mol. Sci. 2017, 18, 611.
Hosick PA, Weeks MF, Hankins MW, Moore KH, Stec DE. Sex-Dependent Effects of HO-1 Deletion from Adipocytes in Mice. International Journal of Molecular Sciences. 2017; 18(3):611.Chicago/Turabian Style
Hosick, Peter A.; Weeks, Mary F.; Hankins, Michael W.; Moore, Kyle H.; Stec, David E. 2017. "Sex-Dependent Effects of HO-1 Deletion from Adipocytes in Mice." Int. J. Mol. Sci. 18, no. 3: 611.
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