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Int. J. Mol. Sci. 2017, 18(3), 611; doi:10.3390/ijms18030611

Sex-Dependent Effects of HO-1 Deletion from Adipocytes in Mice

1
Department of Physiology & Biophysics, Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216, USA
2
Department of Exercise Science and Physical Education, Montclair State University, Montclair, NJ 07043, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Christa Buechler
Received: 3 January 2017 / Revised: 8 March 2017 / Accepted: 9 March 2017 / Published: 11 March 2017
(This article belongs to the Special Issue Adipokines)
View Full-Text   |   Download PDF [3001 KB, uploaded 11 March 2017]   |  

Abstract

Induction of heme oxygenase-1 (HO-1) has been demonstrated to decrease body weight and improve insulin sensitivity in several models of obesity in rodents. To further study the role of HO-1 in adipose tissue, we created an adipose-specific HO-1 knockout mouse model. Male and female mice were fed either a control or a high-fat diet for 30 weeks. Body weights were measured weekly and body composition, fasting blood glucose and insulin levels were determined every six weeks. Adipocyte-specific knockout of HO-1 had no significant effect on body weight in mice fed a high-fat diet but increased body weight in female mice fed a normal-fat diet. Although body weights were not different in females fed a high fat diet, loss of HO-1 in adipocytes resulted in significant alterations in body composition. Adipose-specific HO-1 knockout resulted in increased fasting hyperglycemia and insulinemia in female but not male mice on both diets. Adipose-specific knockout of HO-1 resulted in a significant loss of HO activity and a decrease in the protein levels of adiponectin in adipose tissue. These results demonstrate that loss of HO-1 in adipocytes has greater effects on body fat and fasting hyperglycemia in a sex-dependent fashion and that expression of HO-1 in adipose tissue may have a greater protective role in females as compared to males. View Full-Text
Keywords: obesity; diabetes; bilirubin; Cre recombinase; insulin resistance; adiponectin obesity; diabetes; bilirubin; Cre recombinase; insulin resistance; adiponectin
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MDPI and ACS Style

Hosick, P.A.; Weeks, M.F.; Hankins, M.W.; Moore, K.H.; Stec, D.E. Sex-Dependent Effects of HO-1 Deletion from Adipocytes in Mice. Int. J. Mol. Sci. 2017, 18, 611.

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