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Int. J. Mol. Sci. 2017, 18(3), 594; doi:10.3390/ijms18030594

Multicomponent, Tumor-Homing Chitosan Nanoparticles for Cancer Imaging and Therapy

1
Department of Biomedical Engineering, Yonsei University, 1 Yonseidae-gil, Wonju 26493, Gangwon-do, Korea
2
Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Gyeonggi-do, Korea
*
Authors to whom correspondence should be addressed.
Academic Editors: Hitoshi Sashiwa and Shinsuke Ifuku
Received: 10 January 2017 / Accepted: 6 March 2017 / Published: 8 March 2017
(This article belongs to the Special Issue Chitins 2016)
View Full-Text   |   Download PDF [8918 KB, uploaded 9 March 2017]   |  

Abstract

Current clinical methods for cancer diagnosis and therapy have limitations, although survival periods are increasing as medical technologies develop. In most cancer cases, patient survival is closely related to cancer stage. Late-stage cancer after metastasis is very challenging to cure because current surgical removal of cancer is not precise enough and significantly affects bystander normal tissues. Moreover, the subsequent chemotherapy and radiation therapy affect not only malignant tumors, but also healthy tissues. Nanotechnologies for cancer treatment have the clear objective of solving these issues. Nanoparticles have been developed to more accurately differentiate early-stage malignant tumors and to treat only the tumors while dramatically minimizing side effects. In this review, we focus on recent chitosan-based nanoparticles developed with the goal of accurate cancer imaging and effective treatment. Regarding imaging applications, we review optical and magnetic resonance cancer imaging in particular. Regarding cancer treatments, we review various therapeutic methods that use chitosan-based nanoparticles, including chemo-, gene, photothermal, photodynamic and magnetic therapies. View Full-Text
Keywords: chitosan; nanoparticles; drug delivery; optical imaging; magnetic resonance imaging; chemotherapy; gene therapy; photothermal therapy; photodynamic therapy; hyperthermic therapy chitosan; nanoparticles; drug delivery; optical imaging; magnetic resonance imaging; chemotherapy; gene therapy; photothermal therapy; photodynamic therapy; hyperthermic therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Key, J.; Park, K. Multicomponent, Tumor-Homing Chitosan Nanoparticles for Cancer Imaging and Therapy. Int. J. Mol. Sci. 2017, 18, 594.

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