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Int. J. Mol. Sci. 2017, 18(3), 542; doi:10.3390/ijms18030542

Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications

1
Department of Biomedical Sciences, University of Cagliari, Monserrato I-09042, CA, Italy
2
Department of Chemical and Geological Sciences, University of Cagliari, Monserrato I-09042, CA, Italy
3
Institute of Pharmaceutical Science, King’s College London, London SE1 9NH, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Antonella Piozzi and Iolanda Francolini
Received: 15 January 2017 / Revised: 15 February 2017 / Accepted: 23 February 2017 / Published: 3 March 2017
(This article belongs to the Special Issue Antimicrobial Polymers 2016)
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Abstract

Microbial resistance to conventional antibiotics is one of the most outstanding medical and scientific challenges of our times. Despite the recognised need for new anti-infective agents, however, very few new drugs have been brought to the market and to the clinic in the last three decades. This review highlights the properties of a new class of antibiotics, namely dendrimeric peptides. These intriguing novel compounds, generally made of multiple peptidic sequences linked to an inner branched core, display an array of antibacterial, antiviral and antifungal activities, usually coupled to low haemolytic activity. In addition, several peptides synthesized in oligobranched form proved to be promising tools for the selective treatment of cancer cells. View Full-Text
Keywords: antimicrobial peptides; dendrimers; peptidomimetics; biofilms; antiviral; antifungal; antitumor; model membranes; biophysical methods; NMR; molecular dynamics antimicrobial peptides; dendrimers; peptidomimetics; biofilms; antiviral; antifungal; antitumor; model membranes; biophysical methods; NMR; molecular dynamics
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MDPI and ACS Style

Scorciapino, M.A.; Serra, I.; Manzo, G.; Rinaldi, A.C. Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications. Int. J. Mol. Sci. 2017, 18, 542.

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