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Int. J. Mol. Sci. 2017, 18(2), 445; doi:10.3390/ijms18020445

PET Imaging for Initial Staging and Therapy Assessment in Multiple Myeloma Patients

1
Nantes-Angers Cancer Research Center (CRCNA), University of Nantes, Inserm UMR 1232, 8 quai Moncousu, 44007 Nantes, France
2
Department of Nuclear Medicine, CHU de Nantes, 1 place Alexis Ricordeau, 44093 Nantes, France
3
Department of Nuclear Medicine, ICO-René Gauducheau, Boulevard Jacques Monod, 44805 Saint-Herblain, France
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 27 January 2017 / Revised: 14 February 2017 / Accepted: 15 February 2017 / Published: 18 February 2017
View Full-Text   |   Download PDF [227 KB, uploaded 18 February 2017]

Abstract

Multiple myeloma (MM) is a hematological neoplasm characterized by the clonal proliferation of malignant plasma cells in the bone marrow. MM results in diffuse or focal bone infiltration and extramedullary lesions. Over the past two decades, advances have been made with regard to the diagnosis, staging, treatment, and imaging of MM. Computed tomography (CT) and magnetic resonance imaging (MRI) are currently recommended as the most effective imaging modalities at diagnostic. Yet, recent data from the literature suggest that positron emission tomography combined with computed tomography (PET/CT) using 18F-deoxyglucose (FDG) is a promising technique for initial staging and therapeutic monitoring in this pathology. This paper reviews the recent advances as well as the potential place of a more specific radiopharmaceutical in MM. View Full-Text
Keywords: multiple myeloma; solitary plasmacytoma; PET/CT; therapeutic evaluation multiple myeloma; solitary plasmacytoma; PET/CT; therapeutic evaluation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bailly, C.; Leforestier, R.; Jamet, B.; Carlier, T.; Bourgeois, M.; Guérard, F.; Touzeau, C.; Moreau, P.; Chérel, M.; Kraeber-Bodéré, F.; Bodet-Milin, C. PET Imaging for Initial Staging and Therapy Assessment in Multiple Myeloma Patients. Int. J. Mol. Sci. 2017, 18, 445.

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