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Int. J. Mol. Sci. 2017, 18(2), 450; doi:10.3390/ijms18020450

The Interplay of LncRNA-H19 and Its Binding Partners in Physiological Process and Gastric Carcinogenesis

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1,2,3,4
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1,2,3,4,* and 1,2,3,4,*
1
Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
2
Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
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Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, China
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Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China
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School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
*
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 22 January 2017 / Revised: 12 February 2017 / Accepted: 16 February 2017 / Published: 20 February 2017
View Full-Text   |   Download PDF [2233 KB, uploaded 20 February 2017]   |  

Abstract

Long non-coding RNA (lncRNA), a novel and effective modulator in carcinogenesis, has become a study hotspot in recent years. The imprinted oncofetal lncRNA H19 is one of the first identified imprinted lncRNAs with a high expression level in embryogenesis but is barely detectable in most tissues after birth. Aberrant alterations of H19 expression have been demonstrated in various tumors, including gastric cancer (GC), implicating a crucial role of H19 in cancer progression. As one of the top malignancies in the world, GC has already become a serious concern to public health with poor prognosis. The regulatory roles of H19 in gastric carcinogenesis have been explored by various research groups, which leads to the development of GC therapy. This review comprehensively summarizes the current knowledge of H19 in tumorigenesis, especially in GC pathogenesis, with emphasis on the underneath molecular mechanisms depicted from its functional partners. Furthermore, the accumulated knowledge of H19 will provide better understanding on targeted therapy of GC. View Full-Text
Keywords: lncRNA; H19; gastric cancer lncRNA; H19; gastric cancer
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Zhang, L.; Zhou, Y.; Huang, T.; Cheng, A.S.L.; Yu, J.; Kang, W.; To, K.F. The Interplay of LncRNA-H19 and Its Binding Partners in Physiological Process and Gastric Carcinogenesis. Int. J. Mol. Sci. 2017, 18, 450.

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