Next Article in Journal
The Role of Nerve Growth Factor (NGF) and Its Precursor Forms in Oral Wound Healing
Next Article in Special Issue
A Review: Proteomics in Retinal Artery Occlusion, Retinal Vein Occlusion, Diabetic Retinopathy and Acquired Macular Disorders
Previous Article in Journal
The Mechanisms and Biomedical Applications of an NIR BODIPY-Based Switchable Fluorescent Probe
Previous Article in Special Issue
Proteomic Analysis of Various Rat Ocular Tissues after Ischemia–Reperfusion Injury and Possible Relevance to Acute Glaucoma
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(2), 387; doi:10.3390/ijms18020387

Redox Proteomics and Platelet Activation: Understanding the Redox Proteome to Improve Platelet Quality for Transfusion

1
Transfusion Interrégionale Croix Rouge Suisse SA, Laboratoire de Recherche sur les Produits Sanguins, Route de la Corniche 2, 1066 Epalinges, Switzerland
2
Faculté de Biologie et de Médecine, Université de Lausanne, CH-1011 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: David Sheehan
Received: 16 December 2016 / Revised: 27 January 2017 / Accepted: 7 February 2017 / Published: 11 February 2017
(This article belongs to the Collection Advances in Proteomic Research)
View Full-Text   |   Download PDF [1713 KB, uploaded 11 February 2017]   |  

Abstract

Blood banks use pathogen inactivation (PI) technologies to increase the safety of platelet concentrates (PCs). The characteristics of PI-treated PCs slightly differ from those of untreated PCs, but the underlying reasons are not well understood. One possible cause is the generation of oxidative stress during the PI process. This is of great interest since reactive oxygen species (ROS) act as second messengers in platelet functions. Furthermore, there are links between protein oxidation and phosphorylation, another mechanism that is critical for cell regulation. Current research efforts focus on understanding the underlying mechanisms and identifying new target proteins. Proteomics technologies represent powerful tools for investigating signaling pathways involving ROS and post-translational modifications such as phosphorylation, while quantitative techniques enable the comparison of the platelet resting state versus the stimulated state. In particular, redox cysteine is a key player in platelet activation upon stimulation by different agonists. This review highlights the experiments that have provided insights into the roles of ROS in platelet function and the implications for platelet transfusion, and potentially in diseases such as inflammation and platelet hyperactivity. The review also describes the implication of redox mechanism in platelet storage considerations. View Full-Text
Keywords: activation; aggregation; blood products; phosphorylation; platelet function; platelets; reactive oxygen species; redox cysteine; transfusion activation; aggregation; blood products; phosphorylation; platelet function; platelets; reactive oxygen species; redox cysteine; transfusion
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sonego, G.; Abonnenc, M.; Tissot, J.-D.; Prudent, M.; Lion, N. Redox Proteomics and Platelet Activation: Understanding the Redox Proteome to Improve Platelet Quality for Transfusion. Int. J. Mol. Sci. 2017, 18, 387.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top