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Int. J. Mol. Sci. 2017, 18(5), 907; doi:10.3390/ijms18050907

A Review: Proteomics in Retinal Artery Occlusion, Retinal Vein Occlusion, Diabetic Retinopathy and Acquired Macular Disorders

1
Department of Ophthalmology, Aalborg University Hospital, Hobrovej 18-22, 9000 Aalborg, Denmark
2
Department of Clinical Medicine, Aalborg University, Søndre Skovvej 15, 9000 Aalborg, Denmark
3
Department of Biomedicine, Aarhus University, Ole Worms Allé 3, Building 1182, 024, 8000 Aarhus C, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Charles A. Collyer
Received: 3 January 2017 / Revised: 8 March 2017 / Accepted: 5 April 2017 / Published: 28 April 2017
(This article belongs to the Collection Advances in Proteomic Research)
View Full-Text   |   Download PDF [8234 KB, uploaded 28 April 2017]   |  

Abstract

Retinal artery occlusion (RAO), retinal vein occlusion (RVO), diabetic retinopathy (DR) and age-related macular degeneration (AMD) are frequent ocular diseases with potentially sight-threatening outcomes. In the present review we discuss major findings of proteomic studies of RAO, RVO, DR and AMD, including an overview of ocular proteome changes associated with anti-vascular endothelial growth factor (VEGF) treatments. Despite the severe outcomes of RAO, the proteome of the disease remains largely unstudied. There is also limited knowledge about the proteome of RVO, but proteomic studies suggest that RVO is associated with remodeling of the extracellular matrix and adhesion processes. Proteomic studies of DR have resulted in the identification of potential therapeutic targets such as carbonic anhydrase-I. Proliferative diabetic retinopathy is the most intensively studied stage of DR. Proteomic studies have established VEGF, pigment epithelium-derived factor (PEDF) and complement components as key factors associated with AMD. The aim of this review is to highlight the major milestones in proteomics in RAO, RVO, DR and AMD. Through large-scale protein analyses, proteomics is bringing new important insights into these complex pathological conditions. View Full-Text
Keywords: age-related macular degeneration; biological marker; diabetic retinopathy; mass spectrometry; proteomics; retina; retinal vein occlusion; vascular endothelial growth factor; vitreous body age-related macular degeneration; biological marker; diabetic retinopathy; mass spectrometry; proteomics; retina; retinal vein occlusion; vascular endothelial growth factor; vitreous body
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cehofski, L.J.; Honoré, B.; Vorum, H. A Review: Proteomics in Retinal Artery Occlusion, Retinal Vein Occlusion, Diabetic Retinopathy and Acquired Macular Disorders. Int. J. Mol. Sci. 2017, 18, 907.

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