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Int. J. Mol. Sci. 2017, 18(2), 348; doi:10.3390/ijms18020348

Perindopril Induces TSP-1 Expression in Hypertensive Patients with Endothelial Dysfunction in Chronic Treatment

1
Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, Romania
2
Faculty of Medicine, Victor Babeş University of Medicine and Pharmacy, 2 EftimieMurgu, 300041 Timisoara, Romania
3
Faculty of Pharmacy, VasileGoldis Western University, 86 LiviuRebreanu, 310045 Arad, Romania
*
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 7 December 2016 / Revised: 12 January 2017 / Accepted: 30 January 2017 / Published: 7 February 2017
(This article belongs to the Special Issue Liquid Biopsy for Clinical Application)
View Full-Text   |   Download PDF [1966 KB, uploaded 7 February 2017]   |  

Abstract

Thrombospondin-1 (TSP-1) is a potent endogenous inhibitor of both physiological and pathological angiogenesis, widely studied as a target in drug development for treating cancer. Several studies performed in the cardiovascular field on TSP-1 are contradictory, the role of TSP-1 in the physiopathology of cardiovascular disorders (CVDs) being, for the moment, incompletely understood and may be due to the presence of several domains in its structure which can stimulate many cellular receptors. It has been reported to inhibit NO-mediated signaling and to act on the angiogenesis, tissue perfusion, endothelial cell proliferation, and homeostasis, so we aimed to quantify the effect Perindopril has on TSP-1 plasma levels in hypertensive patients with endothelial dysfunction in comparison with other antihypertensive drugs, such as beta blockers, calcium channel blockers, and diuretics, in a chronic treatment. As a conclusion, patients under treatment with Perindopril had increased plasma levels of TSP-1 compared with other hypertensive patients and with the control group. The results of this study confirms the pleiotropic properties of Perindopril: anti-proliferative, anti-inflammatory, with effects showed by quantifying a single biomarker: TSP-1. View Full-Text
Keywords: TSP-1; thrombospondin-1; endothelial dysfunction; essential arterial hypertension; perindopril; antihypertensive drugs; anti-inflammatory; anti-proliferative; angiotensin-converting enzyme (ACE) inhibitors TSP-1; thrombospondin-1; endothelial dysfunction; essential arterial hypertension; perindopril; antihypertensive drugs; anti-inflammatory; anti-proliferative; angiotensin-converting enzyme (ACE) inhibitors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Buda, V.; Andor, M.; Petrescu, L.; Cristescu, C.; Baibata, D.E.; Voicu, M.; Munteanu, M.; Citu, I.; Muntean, C.; Cretu, O.; Tomescu, M.C. Perindopril Induces TSP-1 Expression in Hypertensive Patients with Endothelial Dysfunction in Chronic Treatment. Int. J. Mol. Sci. 2017, 18, 348.

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