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Int. J. Mol. Sci. 2017, 18(2), 347; doi:10.3390/ijms18020347

Anti-Inflammatory Activity of Sanghuangporus sanghuang Mycelium

1
School of Pharmacy, China Medical University, Taichung 404, Taiwan
2
Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan
3
Department of Biology, National Museum of Natural Science, Taichung 404, Taiwan
4
Grape King Biotechnology Center, Chung-Li City 320, Taiwan
5
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editors: Paula Andrade and Patrícia Valentão
Received: 29 November 2016 / Revised: 18 January 2017 / Accepted: 20 January 2017 / Published: 7 February 2017
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents)
View Full-Text   |   Download PDF [7620 KB, uploaded 7 February 2017]   |  

Abstract

Acute lung injury (ALI) is characterized by inflammation of the lung tissue and oxidative injury caused by excessive accumulation of reactive oxygen species. Studies have suggested that anti-inflammatory or antioxidant agents could be used for the treatment of ALI with a good outcome. Therefore, our study aimed to test whether the mycelium extract of Sanghuangporus sanghuang (SS-1), believed to exhibit antioxidant and anti-inflammatory properties, could be used against the excessive inflammatory response associated with lipopolysaccharides (LPS)-induced ALI in mice and to investigate its possible mechanism of action. The experimental results showed that the administration of SS-1 could inhibit LPS-induced inflammation. SS-1 could reduce the number of inflammatory cells, inhibit myeloperoxidase (MPO) activity, regulate the TLR4/PI3K/Akt/mTOR pathway and the signal transduction of NF-κB and MAPK pathways in the lung tissue, and inhibit high mobility group box-1 protein 1 (HNGB1) activity in BALF. In addition, SS-1 could affect the synthesis of antioxidant enzymes Heme oxygenase 1 (HO-1) and Thioredoxin-1 (Trx-1) in the lung tissue and regulate signal transduction in the KRAB-associated protein-1 (KAP1)/nuclear factor erythroid-2-related factor Nrf2/Kelch Like ECH associated Protein 1 (Keap1) pathway. Histological results showed that administration of SS-1 prior to induction could inhibit the large-scale LPS-induced neutrophil infiltration of the lung tissue. Therefore, based on all experimental results, we propose that SS-1 exhibits a protective effect against LPS-induced ALI in mice. The mycelium of S. sanghuang can potentially be used for the treatment or prevention of inflammation-related diseases. View Full-Text
Keywords: acute lung injury; mycelium of Sanghuangporus sanghuang; lipopolysaccharide; KAP1/Nrf2 pathway; PI3K/Akt/mTOR pathways; HO-1; HNGB acute lung injury; mycelium of Sanghuangporus sanghuang; lipopolysaccharide; KAP1/Nrf2 pathway; PI3K/Akt/mTOR pathways; HO-1; HNGB
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MDPI and ACS Style

Lin, W.-C.; Deng, J.-S.; Huang, S.-S.; Wu, S.-H.; Chen, C.-C.; Lin, W.-R.; Lin, H.-Y.; Huang, G.-J. Anti-Inflammatory Activity of Sanghuangporus sanghuang Mycelium. Int. J. Mol. Sci. 2017, 18, 347.

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