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Int. J. Mol. Sci. 2017, 18(2), 279; doi:10.3390/ijms18020279

Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice

1
Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan
2
Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan
3
Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, Tottori 680-8550, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Bing Yan
Received: 11 December 2016 / Revised: 12 January 2017 / Accepted: 24 January 2017 / Published: 27 January 2017
(This article belongs to the Special Issue Chitins 2016)
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Abstract

This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs. View Full-Text
Keywords: surface deacetylated chitin nanofiber; chitosan; mucositis; 5-fluorouracil; apoptosis surface deacetylated chitin nanofiber; chitosan; mucositis; 5-fluorouracil; apoptosis
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Koizumi, R.; Azuma, K.; Izawa, H.; Morimoto, M.; Ochi, K.; Tsuka, T.; Imagawa, T.; Osaki, T.; Ito, N.; Okamoto, Y.; Saimoto, H.; Ifuku, S. Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice. Int. J. Mol. Sci. 2017, 18, 279.

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