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Int. J. Mol. Sci. 2017, 18(11), 2454; https://doi.org/10.3390/ijms18112454

Cytotoxicity of Poly(Alkyl Cyanoacrylate) Nanoparticles

1
SINTEF Materials and Chemistry, Sem Sælands vei 2A, 7034 Trondheim, Norway
2
Department of Physics, Norwegian University of Science and Technology, Høgskoleringen 5, 7491 Trondheim, Norway
3
Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital—The Norwegian Radium Hospital, 0379 Oslo, Norway
4
Center for Cancer Biomedicine, Faculty of Medicine, University of Oslo, 0379 Oslo, Norway
5
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 8905 MH, 7491 Trondheim, Norway
6
Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316 Oslo, Norway
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 17 October 2017 / Revised: 13 November 2017 / Accepted: 15 November 2017 / Published: 18 November 2017
(This article belongs to the Collection Bioactive Nanoparticles)
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Abstract

Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated in several cell lines with different methods and on multiple nanoparticle batches. Here we report the toxicity of poly(alkyl cyanoacrylate) nanoparticles in 12 different cell lines after synthesizing and analyzing 19 different nanoparticle batches and report that large variations were obtained when using different cell lines or various toxicity assays. Surprisingly, we found that nanoparticles with intermediate degradation rates were less toxic than particles that were degraded faster or more slowly in a cell-free system. The toxicity did not vary significantly with either the three different combinations of polyethylene glycol surfactants or with particle size (range 100–200 nm). No acute pro- or anti-inflammatory activity on cells in whole blood was observed. View Full-Text
Keywords: nanoparticles; PACA; cytotoxicity; nanotoxicology; high-throughput screening nanoparticles; PACA; cytotoxicity; nanotoxicology; high-throughput screening
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sulheim, E.; Iversen, T.-G.; To Nakstad, V.; Klinkenberg, G.; Sletta, H.; Schmid, R.; Hatletveit, A.R.; Wågbø, A.M.; Sundan, A.; Skotland, T.; Sandvig, K.; Mørch, Ý. Cytotoxicity of Poly(Alkyl Cyanoacrylate) Nanoparticles. Int. J. Mol. Sci. 2017, 18, 2454.

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