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Int. J. Mol. Sci. 2017, 18(11), 2438; https://doi.org/10.3390/ijms18112438

Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain

1
Department of Genetics, Cell Biology & Development, University of Minnesota, 420 Washington Ave SE, Minneapolis, MN 55455, USA
2
Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA
*
Authors to whom correspondence should be addressed.
Received: 13 October 2017 / Revised: 10 November 2017 / Accepted: 14 November 2017 / Published: 17 November 2017
(This article belongs to the Special Issue DNA Topoisomerases)
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Abstract

DNA Topoisomerase IIα (Topo IIα) is a ubiquitous enzyme in eukaryotes that performs the strand passage reaction where a double helix of DNA is passed through a second double helix. This unique reaction is critical for numerous cellular processes. However, the enzyme also possesses a C-terminal domain (CTD) that is largely dispensable for the strand passage reaction but is nevertheless important for the fidelity of cell division. Recent studies have expanded our understanding of the roles of the Topo IIα CTD, in particular in mitotic mechanisms where the CTD is modified by Small Ubiquitin-like Modifier (SUMO), which in turn provides binding sites for key regulators of mitosis. View Full-Text
Keywords: Topoisomerase II; SUMO; C-terminal domain; mitosis; Aurora B; Haspin; Claspin; metaphase checkpoint Topoisomerase II; SUMO; C-terminal domain; mitosis; Aurora B; Haspin; Claspin; metaphase checkpoint
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Clarke, D.J.; Azuma, Y. Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain. Int. J. Mol. Sci. 2017, 18, 2438.

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