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Int. J. Mol. Sci. 2017, 18(11), 2395; doi:10.3390/ijms18112395

Impact of Labile Zinc on Heart Function: From Physiology to Pathophysiology

Department of Biophysics, Ankara University, Faculty of Medicine, 06100 Ankara, Turkey
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Received: 14 October 2017 / Revised: 2 November 2017 / Accepted: 8 November 2017 / Published: 12 November 2017
(This article belongs to the Special Issue Zinc Signaling in Physiology and Pathogenesis)
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Abstract

Zinc plays an important role in biological systems as bound and histochemically reactive labile Zn2+. Although Zn2+ concentration is in the nM range in cardiomyocytes at rest and increases dramatically under stimulation, very little is known about precise mechanisms controlling the intracellular distribution of Zn2+ and its variations during cardiac function. Recent studies are focused on molecular and cellular aspects of labile Zn2+ and its homeostasis in mammalian cells and growing evidence clarified the molecular mechanisms underlying Zn2+-diverse functions in the heart, leading to the discovery of novel physiological functions of labile Zn2+ in parallel to the discovery of subcellular localization of Zn2+-transporters in cardiomyocytes. Additionally, important experimental data suggest a central role of intracellular labile Zn2+ in excitation-contraction coupling in cardiomyocytes by shaping Ca2+ dynamics. Cellular labile Zn2+ is tightly regulated against its adverse effects through either Zn2+-transporters, Zn2+-binding molecules or Zn2+-sensors, and, therefore plays a critical role in cellular signaling pathways. The present review summarizes the current understanding of the physiological role of cellular labile Zn2+ distribution in cardiomyocytes and how a remodeling of cellular Zn2+-homeostasis can be important in proper cell function with Zn2+-transporters under hyperglycemia. We also emphasize the recent investigations on Zn2+-transporter functions from the standpoint of human heart health to diseases together with their clinical interest as target proteins in the heart under pathological condition, such as diabetes. View Full-Text
Keywords: zinc transporters; intracellular labile zinc; heart failure; endoplasmic reticulum stress; left ventricle zinc transporters; intracellular labile zinc; heart failure; endoplasmic reticulum stress; left ventricle
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Turan, B.; Tuncay, E. Impact of Labile Zinc on Heart Function: From Physiology to Pathophysiology. Int. J. Mol. Sci. 2017, 18, 2395.

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