The Impact of Synaptic Zn2+ Dynamics on Cognition and Its Decline
AbstractThe basal levels of extracellular Zn2+ are in the range of low nanomolar concentrations and less attention has been paid to Zn2+, compared to Ca2+, for synaptic activity. However, extracellular Zn2+ is necessary for synaptic activity. The basal levels of extracellular zinc are age-dependently increased in the rat hippocampus, implying that the basal levels of extracellular Zn2+ are also increased age-dependently and that extracellular Zn2+ dynamics are linked with age-related cognitive function and dysfunction. In the hippocampus, the influx of extracellular Zn2+ into postsynaptic neurons, which is often linked with Zn2+ release from neuron terminals, is critical for cognitive activity via long-term potentiation (LTP). In contrast, the excess influx of extracellular Zn2+ into postsynaptic neurons induces cognitive decline. Interestingly, the excess influx of extracellular Zn2+ more readily occurs in aged dentate granule cells and intracellular Zn2+-buffering, which is assessed with ZnAF-2DA, is weakened in the aged dentate granule cells. Characteristics (easiness) of extracellular Zn2+ influx seem to be linked with the weakened intracellular Zn2+-buffering in the aged dentate gyrus. This paper deals with the impact of synaptic Zn2+ signaling on cognition and its decline in comparison with synaptic Ca2+ signaling. View Full-Text
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Takeda, A.; Tamano, H. The Impact of Synaptic Zn2+ Dynamics on Cognition and Its Decline. Int. J. Mol. Sci. 2017, 18, 2411.
Takeda A, Tamano H. The Impact of Synaptic Zn2+ Dynamics on Cognition and Its Decline. International Journal of Molecular Sciences. 2017; 18(11):2411.Chicago/Turabian Style
Takeda, Atsushi; Tamano, Hanuna. 2017. "The Impact of Synaptic Zn2+ Dynamics on Cognition and Its Decline." Int. J. Mol. Sci. 18, no. 11: 2411.
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