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Int. J. Mol. Sci. 2017, 18(11), 2388; https://doi.org/10.3390/ijms18112388

Inclusion Complexes of Copaiba (Copaifera multijuga Hayne) Oleoresin and Cyclodextrins: Physicochemical Characterization and Anti-Inflammatory Activity

1
Department of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN 59012-570, Brazil
2
Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil
3
Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, PE 50740-520, Brazil
4
Graduate Program in Biotechnology, Laureate International Universities—Universidade Potiguar (UnP), Natal, RN 59056-000, Brazil
5
Department of Chemistry, Institute of Exact Sciences, Federal University of Amazonas, Manaus, AM 69077-000, Brazil
*
Author to whom correspondence should be addressed.
Received: 9 October 2017 / Revised: 25 October 2017 / Accepted: 26 October 2017 / Published: 18 November 2017
(This article belongs to the Special Issue Effective Mechanisms of Plant Bioactive Essential Fats and Oils)
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Abstract

Complexation with cyclodextrins (CDs) is a technique that has been extensively used to increase the aqueous solubility of oils and improve their stability. In addition, this technique has been used to convert oils into solid materials. This work aims to develop inclusion complexes of Copaifera multijuga oleoresin (CMO), which presents anti-inflammatory activity, with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) by kneading (KND) and slurry (SL) methods. Physicochemical characterization was performed to verify the occurrence of interactions between CMO and the cyclodextrins. Carrageenan-induced hind paw edema in mice was carried out to evaluate the anti-inflammatory activity of CMO alone as well as complexed with CDs. Physicochemical characterization confirmed the formation of inclusion complex of CMO with both β-CD and HP-β-CD by KND and SL methods. Carrageenan-induced paw edema test showed that the anti-inflammatory activity of CMO was maintained after complexation with β-CD and HP-β-CD, where they were able to decrease the levels of nitrite and myeloperoxidase. In conclusion, this study showed that it is possible to produce inclusion complexes of CMO with CDs by KND and SL methods without any change in CMO’s anti-inflammatory activity. View Full-Text
Keywords: Copaifera multijuga Hayne; copaiba oil; inclusion complex; cyclodextrin; anti-inflammatory activity Copaifera multijuga Hayne; copaiba oil; inclusion complex; cyclodextrin; anti-inflammatory activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pinheiro, J.G.O.; Tavares, E.A.; Silva, S.S.; Félix Silva, J.; Carvalho, Y.M.B.G.; Ferreira, M.R.A.; Araújo, A.A.S.; Barbosa, E.G.; Fernandes Pedrosa, M.F.; Soares, L.A.L.; Azevedo, E.P.; Veiga Júnior, V.F.; Lima, Á.A.N. Inclusion Complexes of Copaiba (Copaifera multijuga Hayne) Oleoresin and Cyclodextrins: Physicochemical Characterization and Anti-Inflammatory Activity. Int. J. Mol. Sci. 2017, 18, 2388.

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